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SAK3 Administration Improves Spine Abnormalities and Cognitive Deficits in App(NL-G-F/NL-G-F) Knock-in Mice by Increasing Proteasome Activity through CaMKII/Rpt6 Signaling

Alzheimer’s disease (AD) is the most common form of dementia and is characterized by neuropathological hallmarks consisting of accumulation of extracellular amyloid-β (Aβ) plaques and intracellular neurofibrillary tangles (NFT). Recently, we have identified a new AD therapeutic candidate, ethyl-8′-m...

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Detalles Bibliográficos
Autores principales:	Izumi, Hisanao, Kawahata, Ichiro, Shinoda, Yasuharu, Helmstetter, Fred J., Fukunaga, Kohji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312612/ https://www.ncbi.nlm.nih.gov/pubmed/32481611 http://dx.doi.org/10.3390/ijms21113833

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