Cargando…
Curcumin—A Viable Agent for Better Bladder Cancer Treatment
Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One o...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312715/ https://www.ncbi.nlm.nih.gov/pubmed/32466578 http://dx.doi.org/10.3390/ijms21113761 |
_version_ | 1783549795075358720 |
---|---|
author | Rutz, Jochen Janicova, Andrea Woidacki, Katja Chun, Felix K.-H. Blaheta, Roman A. Relja, Borna |
author_facet | Rutz, Jochen Janicova, Andrea Woidacki, Katja Chun, Felix K.-H. Blaheta, Roman A. Relja, Borna |
author_sort | Rutz, Jochen |
collection | PubMed |
description | Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One of these is curcumin, the principal component of Curcuma longa that has shown chemopreventive effects in experimental cancer models. Clinical and preclinical studies point to its role as a chemosensitizer, and it has been shown to protect organs from toxicity induced by chemotherapy. These properties indicate that curcumin could hold promise as a candidate for additive cancer treatment. This review evaluates the relevance of curcumin as an integral part of therapy for bladder cancer. |
format | Online Article Text |
id | pubmed-7312715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73127152020-06-26 Curcumin—A Viable Agent for Better Bladder Cancer Treatment Rutz, Jochen Janicova, Andrea Woidacki, Katja Chun, Felix K.-H. Blaheta, Roman A. Relja, Borna Int J Mol Sci Review Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One of these is curcumin, the principal component of Curcuma longa that has shown chemopreventive effects in experimental cancer models. Clinical and preclinical studies point to its role as a chemosensitizer, and it has been shown to protect organs from toxicity induced by chemotherapy. These properties indicate that curcumin could hold promise as a candidate for additive cancer treatment. This review evaluates the relevance of curcumin as an integral part of therapy for bladder cancer. MDPI 2020-05-26 /pmc/articles/PMC7312715/ /pubmed/32466578 http://dx.doi.org/10.3390/ijms21113761 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Rutz, Jochen Janicova, Andrea Woidacki, Katja Chun, Felix K.-H. Blaheta, Roman A. Relja, Borna Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title | Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title_full | Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title_fullStr | Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title_full_unstemmed | Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title_short | Curcumin—A Viable Agent for Better Bladder Cancer Treatment |
title_sort | curcumin—a viable agent for better bladder cancer treatment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312715/ https://www.ncbi.nlm.nih.gov/pubmed/32466578 http://dx.doi.org/10.3390/ijms21113761 |
work_keys_str_mv | AT rutzjochen curcuminaviableagentforbetterbladdercancertreatment AT janicovaandrea curcuminaviableagentforbetterbladdercancertreatment AT woidackikatja curcuminaviableagentforbetterbladdercancertreatment AT chunfelixkh curcuminaviableagentforbetterbladdercancertreatment AT blahetaromana curcuminaviableagentforbetterbladdercancertreatment AT reljaborna curcuminaviableagentforbetterbladdercancertreatment |