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Curcumin—A Viable Agent for Better Bladder Cancer Treatment

Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One o...

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Detalles Bibliográficos
Autores principales: Rutz, Jochen, Janicova, Andrea, Woidacki, Katja, Chun, Felix K.-H., Blaheta, Roman A., Relja, Borna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312715/
https://www.ncbi.nlm.nih.gov/pubmed/32466578
http://dx.doi.org/10.3390/ijms21113761
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author Rutz, Jochen
Janicova, Andrea
Woidacki, Katja
Chun, Felix K.-H.
Blaheta, Roman A.
Relja, Borna
author_facet Rutz, Jochen
Janicova, Andrea
Woidacki, Katja
Chun, Felix K.-H.
Blaheta, Roman A.
Relja, Borna
author_sort Rutz, Jochen
collection PubMed
description Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One of these is curcumin, the principal component of Curcuma longa that has shown chemopreventive effects in experimental cancer models. Clinical and preclinical studies point to its role as a chemosensitizer, and it has been shown to protect organs from toxicity induced by chemotherapy. These properties indicate that curcumin could hold promise as a candidate for additive cancer treatment. This review evaluates the relevance of curcumin as an integral part of therapy for bladder cancer.
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spelling pubmed-73127152020-06-26 Curcumin—A Viable Agent for Better Bladder Cancer Treatment Rutz, Jochen Janicova, Andrea Woidacki, Katja Chun, Felix K.-H. Blaheta, Roman A. Relja, Borna Int J Mol Sci Review Although the therapeutic armamentarium for bladder cancer has considerably widened in the last few years, severe side effects and the development of resistance hamper long-term treatment success. Thus, patients turn to natural plant products as alternative or complementary therapeutic options. One of these is curcumin, the principal component of Curcuma longa that has shown chemopreventive effects in experimental cancer models. Clinical and preclinical studies point to its role as a chemosensitizer, and it has been shown to protect organs from toxicity induced by chemotherapy. These properties indicate that curcumin could hold promise as a candidate for additive cancer treatment. This review evaluates the relevance of curcumin as an integral part of therapy for bladder cancer. MDPI 2020-05-26 /pmc/articles/PMC7312715/ /pubmed/32466578 http://dx.doi.org/10.3390/ijms21113761 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rutz, Jochen
Janicova, Andrea
Woidacki, Katja
Chun, Felix K.-H.
Blaheta, Roman A.
Relja, Borna
Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title_full Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title_fullStr Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title_full_unstemmed Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title_short Curcumin—A Viable Agent for Better Bladder Cancer Treatment
title_sort curcumin—a viable agent for better bladder cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312715/
https://www.ncbi.nlm.nih.gov/pubmed/32466578
http://dx.doi.org/10.3390/ijms21113761
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