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Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril

The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are likely in thes...

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Autores principales: Medhora, Meetha, Gasperetti, Tracy, Schamerhorn, Ashley, Gao, Feng, Narayanan, Jayashree, Lazarova, Zelmira, Jacobs, Elizabeth R., Tarima, Sergey, Fish, Brian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312718/
https://www.ncbi.nlm.nih.gov/pubmed/32486174
http://dx.doi.org/10.3390/ijms21113908
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author Medhora, Meetha
Gasperetti, Tracy
Schamerhorn, Ashley
Gao, Feng
Narayanan, Jayashree
Lazarova, Zelmira
Jacobs, Elizabeth R.
Tarima, Sergey
Fish, Brian L.
author_facet Medhora, Meetha
Gasperetti, Tracy
Schamerhorn, Ashley
Gao, Feng
Narayanan, Jayashree
Lazarova, Zelmira
Jacobs, Elizabeth R.
Tarima, Sergey
Fish, Brian L.
author_sort Medhora, Meetha
collection PubMed
description The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are likely in these scenarios. Either exacerbation or mitigation of radiation damage by wound trauma has been previously reported in preclinical studies. Female WAG/RijCmcr rats received 13 Gy X-rays, with partial-body shielding of one leg. Within 2 h, irradiated rats and non-irradiated controls were given full-thickness skin wounds with or without lisinopril, started orally 7 days after irradiation. Morbidity, skin wound area, breathing interval and blood urea nitrogen were measured up to 160 days post-irradiation to independently evaluate wound trauma and DEARE. Wounding exacerbated morbidity in irradiated rats between 5 and 14 days post-irradiation (during the ARS phase), and irradiation delayed wound healing. Wounding did not alter delayed morbidities from radiation pneumonitis or nephropathy after 30 days post-irradiation. Lisinopril did not mitigate wound healing, but markedly decreased morbidity during DEARE from 31 through 160 days. The results derived from this unique model of combined injuries suggest different molecular mechanisms of injury and healing of ARS and DEARE after radiation exposure.
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spelling pubmed-73127182020-06-26 Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril Medhora, Meetha Gasperetti, Tracy Schamerhorn, Ashley Gao, Feng Narayanan, Jayashree Lazarova, Zelmira Jacobs, Elizabeth R. Tarima, Sergey Fish, Brian L. Int J Mol Sci Article The goal of this study is to understand and mitigate the effects of wounds on acute radiation syndrome (ARS) and delayed effects of acute radiation exposure (DEARE), for preparedness against a radiological attack or accident. Combined injuries from concomitant trauma and radiation are likely in these scenarios. Either exacerbation or mitigation of radiation damage by wound trauma has been previously reported in preclinical studies. Female WAG/RijCmcr rats received 13 Gy X-rays, with partial-body shielding of one leg. Within 2 h, irradiated rats and non-irradiated controls were given full-thickness skin wounds with or without lisinopril, started orally 7 days after irradiation. Morbidity, skin wound area, breathing interval and blood urea nitrogen were measured up to 160 days post-irradiation to independently evaluate wound trauma and DEARE. Wounding exacerbated morbidity in irradiated rats between 5 and 14 days post-irradiation (during the ARS phase), and irradiation delayed wound healing. Wounding did not alter delayed morbidities from radiation pneumonitis or nephropathy after 30 days post-irradiation. Lisinopril did not mitigate wound healing, but markedly decreased morbidity during DEARE from 31 through 160 days. The results derived from this unique model of combined injuries suggest different molecular mechanisms of injury and healing of ARS and DEARE after radiation exposure. MDPI 2020-05-30 /pmc/articles/PMC7312718/ /pubmed/32486174 http://dx.doi.org/10.3390/ijms21113908 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Medhora, Meetha
Gasperetti, Tracy
Schamerhorn, Ashley
Gao, Feng
Narayanan, Jayashree
Lazarova, Zelmira
Jacobs, Elizabeth R.
Tarima, Sergey
Fish, Brian L.
Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title_full Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title_fullStr Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title_full_unstemmed Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title_short Wound Trauma Exacerbates Acute, but not Delayed, Effects of Radiation in Rats: Mitigation by Lisinopril
title_sort wound trauma exacerbates acute, but not delayed, effects of radiation in rats: mitigation by lisinopril
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312718/
https://www.ncbi.nlm.nih.gov/pubmed/32486174
http://dx.doi.org/10.3390/ijms21113908
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