Cargando…
Concordance between Thioacetamide-Induced Liver Injury in Rat and Human In Vitro Gene Expression Data
The immense resources required and the ethical concerns for animal-based toxicological studies have driven the development of in vitro and in silico approaches. Recently, we validated our approach in which the expression of a set of genes is uniquely associated with an organ-injury phenotype (injury...
Autores principales: | Schyman, Patric, Printz, Richard L., Estes, Shanea K., O’Brien, Tracy P., Shiota, Masakazu, Wallqvist, Anders |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312807/ https://www.ncbi.nlm.nih.gov/pubmed/32512829 http://dx.doi.org/10.3390/ijms21114017 |
Ejemplares similares
-
Assessing Chemical-Induced Liver Injury In Vivo From In Vitro Gene Expression Data in the Rat: The Case of Thioacetamide Toxicity
por: Schyman, Patric, et al.
Publicado: (2019) -
Identification of the Toxicity Pathways Associated With Thioacetamide-Induced Injuries in Rat Liver and Kidney
por: Schyman, Patric, et al.
Publicado: (2018) -
Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats
por: Pannala, Venkat R., et al.
Publicado: (2020) -
Assessing Kidney Injury Induced by Mercuric Chloride in Guinea Pigs with In Vivo and In Vitro Experiments
por: Goel, Himanshu, et al.
Publicado: (2023) -
Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat
por: Vinnakota, Kalyan C., et al.
Publicado: (2019)