Consolidated BRCA1/2 Variant Interpretation by MH BRCA Correlates with Predicted PARP Inhibitor Efficacy Association by MH Guide

BRCA1/2 variants are prognostic biomarkers for hereditary breast and/or ovarian cancer (HBOC) syndrome and predictive biomarkers for PARP inhibition. In this study, we benchmarked the classification of BRCA1/2 variants from patients with HBOC-related cancer using MH BRCA, a novel computational techn...

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Detalles Bibliográficos
Autores principales: Hirotsu, Yosuke, Schmidt-Edelkraut, Udo, Nakagomi, Hiroshi, Sakamoto, Ikuko, Hartenfeller, Markus, Narang, Ram, Soldatos, Theodoros G., Kaduthanam, Sajo, Wang, Xiaoyue, Hettich, Stephan, Brock, Stephan, Jackson, David B., Omata, Masao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312854/
https://www.ncbi.nlm.nih.gov/pubmed/32486089
http://dx.doi.org/10.3390/ijms21113895

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