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Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease

Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals an...

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Autores principales: Khare, Tripti, Palakurthi, Sushesh Srivatsa, Shah, Brijesh M., Palakurthi, Srinath, Khare, Sharad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312938/
https://www.ncbi.nlm.nih.gov/pubmed/32486445
http://dx.doi.org/10.3390/ijms21113956
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author Khare, Tripti
Palakurthi, Sushesh Srivatsa
Shah, Brijesh M.
Palakurthi, Srinath
Khare, Sharad
author_facet Khare, Tripti
Palakurthi, Sushesh Srivatsa
Shah, Brijesh M.
Palakurthi, Srinath
Khare, Sharad
author_sort Khare, Tripti
collection PubMed
description Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. Additionally, many of them modify enzymatic activity, alleviate oxidative stress, and downregulate pro-inflammatory transcriptional factors and cytokine secretion. Translational significance of natural nanomedicine and strategies to investigate future natural product-based nanomedicine is discussed. Our focus in this review is to summarize the use of phytochemicals and macromolecules encapsulated in nanoparticles for the treatment of IBD and IBD-associated colorectal cancer.
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spelling pubmed-73129382020-06-29 Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease Khare, Tripti Palakurthi, Sushesh Srivatsa Shah, Brijesh M. Palakurthi, Srinath Khare, Sharad Int J Mol Sci Review Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. Additionally, many of them modify enzymatic activity, alleviate oxidative stress, and downregulate pro-inflammatory transcriptional factors and cytokine secretion. Translational significance of natural nanomedicine and strategies to investigate future natural product-based nanomedicine is discussed. Our focus in this review is to summarize the use of phytochemicals and macromolecules encapsulated in nanoparticles for the treatment of IBD and IBD-associated colorectal cancer. MDPI 2020-05-31 /pmc/articles/PMC7312938/ /pubmed/32486445 http://dx.doi.org/10.3390/ijms21113956 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Khare, Tripti
Palakurthi, Sushesh Srivatsa
Shah, Brijesh M.
Palakurthi, Srinath
Khare, Sharad
Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title_full Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title_fullStr Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title_full_unstemmed Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title_short Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease
title_sort natural product-based nanomedicine in treatment of inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7312938/
https://www.ncbi.nlm.nih.gov/pubmed/32486445
http://dx.doi.org/10.3390/ijms21113956
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