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HMCES Maintains Replication Fork Progression and Prevents Double-Strand Breaks in Response to APOBEC Deamination and Abasic Site Formation

5-Hydroxymethylcytosine (5hmC) binding, ES-cell-specific (HMCES) crosslinks to apurinic or apyrimidinic (AP, abasic) sites in single-strand DNA (ssDNA). To determine whether HMCES responds to the ssDNA abasic site in cells, we exploited the activity of apolipoprotein B mRNA-editing enzyme catalytic...

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Detalles Bibliográficos
Autores principales:	Mehta, Kavi P.M., Lovejoy, Courtney A., Zhao, Runxiang, Heintzman, Darren R., Cortez, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313144/ https://www.ncbi.nlm.nih.gov/pubmed/32492421 http://dx.doi.org/10.1016/j.celrep.2020.107705

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