Cargando…

Reversal of β-Amyloid-Induced Microglial Toxicity In Vitro by Activation of Fpr2/3

Microglial inflammatory activity is thought to be a major contributor to the pathology of neurodegenerative conditions such as Alzheimer's disease (AD), and strategies to restrain their behaviour are under active investigation. Classically, anti-inflammatory approaches are aimed at suppressing...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wickstead, Edward S., Karim, Husnain A., Manuel, Roberta E., Biggs, Christopher S., Getting, Stephen J., McArthur, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313167/ https://www.ncbi.nlm.nih.gov/pubmed/32617132 http://dx.doi.org/10.1155/2020/2139192

Ejemplares similares

Stimulation of the Pro-Resolving Receptor Fpr2 Reverses Inflammatory Microglial Activity by Suppressing NFκB Activity
por: Wickstead, Edward S., et al.
Publicado: (2023)

Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1
por: Loiola, Rodrigo Azevedo, et al.
Publicado: (2019)

Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
por: Wickstead, Edward S., et al.
Publicado: (2022)

α(1)-antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-β-induced toxicity
por: Gold, Maike, et al.
Publicado: (2014)

FPR Ligands
por: Liu, Ying, et al.
Publicado: (2013)

Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: ASSOCIATION WITH CELL PROTECTION FROM APOPTOSIS
por: Thompson, Dawn, et al.
Publicado: (2014)

Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2
por: Zhuang, Youwen, et al.
Publicado: (2022)

Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid‐β 1‐42
por: Vadukul, Devkee M., et al.
Publicado: (2017)

Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease
por: Pan, Xiao-dong, et al.
Publicado: (2011)

Microglial responses to amyloid β peptide opsonization and indomethacin treatment
por: Strohmeyer, Ronald, et al.
Publicado: (2005)

Manganese Exposure Aggravates β-Amyloid Pathology by Microglial Activation
por: Lin, Geng, et al.
Publicado: (2020)

Functions of resolvin D1-ALX/FPR2 receptor interaction in the hemoglobin-induced microglial inflammatory response and neuronal injury
por: Liu, Guang-Jie, et al.
Publicado: (2020)

Structural basis of FPR2 in recognition of Aβ(42) and neuroprotection by humanin
por: Zhu, Ya, et al.
Publicado: (2022)

Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages
por: Marutani, Takayuki, et al.
Publicado: (2021)

Distinct modulation of microglial amyloid β phagocytosis and migration by neuropeptides(i)
por: Fleisher-Berkovich, Sigal, et al.
Publicado: (2010)

An “Amyloid‐β Cleaner” for the Treatment of Alzheimer's Disease by Normalizing Microglial Dysfunction
por: Liu, Ruiyuan, et al.
Publicado: (2019)

Acute-serum amyloid A and A-SAA-derived peptides as formyl peptide receptor (FPR) 2 ligands
por: Abouelasrar Salama, Sara, et al.
Publicado: (2023)

The Toxicity of Amyloid β Oligomers
por: Zhao, Li Na, et al.
Publicado: (2012)

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
por: Wang, Yaming, et al.
Publicado: (2016)

The Effects of Latrepirdine on Amyloid-β Aggregation and Toxicity
por: Porter, Tenielle, et al.
Publicado: (2016)

Cudrania cochinchinensis attenuates amyloid β protein-mediated microglial activation and promotes glia-related clearance of amyloid β protein
por: Wang, Chung-Jen, et al.
Publicado: (2013)

The ambiguous role of FPR1 in immunity and inflammation
por: Vacchelli, Erika, et al.
Publicado: (2020)

Poly(ADP-ribose)polymerase-1 modulates microglial responses to amyloid β
por: Kauppinen, Tiina M, et al.
Publicado: (2011)

Cu(II) enhances the effect of Alzheimer’s amyloid-β peptide on microglial activation
por: Yu, Fengxiang, et al.
Publicado: (2015)

Alginate-Derived Oligosaccharide Inhibits Neuroinflammation and Promotes Microglial Phagocytosis of β-Amyloid
por: Zhou, Rui, et al.
Publicado: (2015)

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s Disease
por: Prakash, Priya, et al.
Publicado: (2023)

Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease
por: Stepanov, Yurii V., et al.
Publicado: (2022)

T1AM/TAAR1 System Reduces Inflammatory Response and β-Amyloid Toxicity in Human Microglial HMC3 Cell Line
por: Polini, Beatrice, et al.
Publicado: (2023)

The Toxicity and Polymorphism of β-Amyloid Oligomers
por: Huang, Ya-ru, et al.
Publicado: (2020)

N-Formylpeptides Induce Two Distinct Concentration Optima for Mouse Neutrophil Chemotaxis by Differential Interaction with Two N-Formylpeptide Receptor (Fpr) Subtypes: Molecular Characterization of Fpr2, a Second Mouse Neutrophil Fpr
por: Hartt, Jennifer K., et al.
Publicado: (1999)

Amyloid β-Sheet Mimics that Antagonize Amyloid Aggregation and Reduce Amyloid Toxicity
por: Cheng, Pin-Nan, et al.
Publicado: (2012)

Identification and validation of FPR1, FPR2, IL17RA and TLR7 as immunogenic cell death related genes in osteoarthritis
por: Ren, Tingting, et al.
Publicado: (2023)

Microfluidic Chemotaxis Platform for Differentiating the Roles of Soluble and Bound Amyloid-β on Microglial Accumulation
por: Cho, Hansang, et al.
Publicado: (2013)

Role of microglial amylin receptors in mediating beta amyloid (Aβ)-induced inflammation
por: Fu, Wen, et al.
Publicado: (2017)

Inflammatory factors and amyloid β-induced microglial polarization promote inflammatory crosstalk with astrocytes
por: Xie, Lushuang, et al.
Publicado: (2020)

Microenvironment involved in FPR1 expression by human glioblastomas
por: Boer, J. C., et al.
Publicado: (2015)

FPR1 is the plague receptor on host immune cells
por: Osei-Owusu, Patrick, et al.
Publicado: (2019)

The neuroprotective role of microglial cells against amyloid beta‐mediated toxicity in organotypic hippocampal slice cultures
por: Richter, Maren, et al.
Publicado: (2020)

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity
por: Zhang, Dan, et al.
Publicado: (2011)

Formation of Toxic Amyloid Fibrils by Amyloid β-Protein on Ganglioside Clusters
por: Matsuzaki, Katsumi
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_m0f18u2a9oopn1ij9fa66ccdee