The genetic and pharmacogenomic landscape of snoRNAs in human cancer

Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized. Using the genotype and snoRNA expression data from The Cancer Genome Atlas, we characterized the effects of...

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Autores principales: Liu, Yaoming, Ruan, Hang, Li, Shengli, Ye, Youqiong, Hong, Wei, Gong, Jing, Zhang, Zhao, Jing, Ying, Zhang, Xiulan, Diao, Lixia, Han, Leng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313177/
https://www.ncbi.nlm.nih.gov/pubmed/32576192
http://dx.doi.org/10.1186/s12943-020-01228-z
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author Liu, Yaoming
Ruan, Hang
Li, Shengli
Ye, Youqiong
Hong, Wei
Gong, Jing
Zhang, Zhao
Jing, Ying
Zhang, Xiulan
Diao, Lixia
Han, Leng
author_facet Liu, Yaoming
Ruan, Hang
Li, Shengli
Ye, Youqiong
Hong, Wei
Gong, Jing
Zhang, Zhao
Jing, Ying
Zhang, Xiulan
Diao, Lixia
Han, Leng
author_sort Liu, Yaoming
collection PubMed
description Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized. Using the genotype and snoRNA expression data from The Cancer Genome Atlas, we characterized the effects of genetic variants on snoRNAs across 29 cancer types and further linked related alleles with patient survival as well as genome-wide association study risk loci. Furthermore, we characterized the impact of snoRNA expression on drug response in patients to facilitate the clinical utility of snoRNAs in cancer. We also developed a user-friendly data resource, GPSno (http://hanlab.uth.edu/GPSno), with multiple modules for researchers to visualize, browse, and download multi-dimensional data. Our study provides a comprehensive genetic and pharmacogenomic landscape of snoRNAs, which will shed light on future clinical considerations for the development of snoRNA-based targeted therapies.
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spelling pubmed-73131772020-06-24 The genetic and pharmacogenomic landscape of snoRNAs in human cancer Liu, Yaoming Ruan, Hang Li, Shengli Ye, Youqiong Hong, Wei Gong, Jing Zhang, Zhao Jing, Ying Zhang, Xiulan Diao, Lixia Han, Leng Mol Cancer Letter to the Editor Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized. Using the genotype and snoRNA expression data from The Cancer Genome Atlas, we characterized the effects of genetic variants on snoRNAs across 29 cancer types and further linked related alleles with patient survival as well as genome-wide association study risk loci. Furthermore, we characterized the impact of snoRNA expression on drug response in patients to facilitate the clinical utility of snoRNAs in cancer. We also developed a user-friendly data resource, GPSno (http://hanlab.uth.edu/GPSno), with multiple modules for researchers to visualize, browse, and download multi-dimensional data. Our study provides a comprehensive genetic and pharmacogenomic landscape of snoRNAs, which will shed light on future clinical considerations for the development of snoRNA-based targeted therapies. BioMed Central 2020-06-23 /pmc/articles/PMC7313177/ /pubmed/32576192 http://dx.doi.org/10.1186/s12943-020-01228-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Liu, Yaoming
Ruan, Hang
Li, Shengli
Ye, Youqiong
Hong, Wei
Gong, Jing
Zhang, Zhao
Jing, Ying
Zhang, Xiulan
Diao, Lixia
Han, Leng
The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title_full The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title_fullStr The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title_full_unstemmed The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title_short The genetic and pharmacogenomic landscape of snoRNAs in human cancer
title_sort genetic and pharmacogenomic landscape of snornas in human cancer
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313177/
https://www.ncbi.nlm.nih.gov/pubmed/32576192
http://dx.doi.org/10.1186/s12943-020-01228-z
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