The emerging roles of circular RNAs in ovarian cancer

Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess sever...

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Autores principales: Yang, Xuejing, Mei, Jie, Wang, Huiyu, Gu, Dingyi, Ding, Junli, Liu, Chaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313187/
https://www.ncbi.nlm.nih.gov/pubmed/32587475
http://dx.doi.org/10.1186/s12935-020-01367-9
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author Yang, Xuejing
Mei, Jie
Wang, Huiyu
Gu, Dingyi
Ding, Junli
Liu, Chaoying
author_facet Yang, Xuejing
Mei, Jie
Wang, Huiyu
Gu, Dingyi
Ding, Junli
Liu, Chaoying
author_sort Yang, Xuejing
collection PubMed
description Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Ovarian cancer (OvCa) is one of the most aggressive malignant diseases affecting the lives of thousands of women worldwide, and the majority of OvCa cases are diagnosed at advanced stages. Accumulating evidence has revealed the significant roles of circRNAs in the occurrence and progression of OvCa, indicating the function of circRNAs as promising biomarkers and their therapeutic relevance in this disease. This review aims to summarize the mechanisms by which circRNAs mediate OvCa progression as well as their diagnostic and prognostic values in OvCa.
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spelling pubmed-73131872020-06-24 The emerging roles of circular RNAs in ovarian cancer Yang, Xuejing Mei, Jie Wang, Huiyu Gu, Dingyi Ding, Junli Liu, Chaoying Cancer Cell Int Review Circular RNA (circRNA) is a novel class of regulatory noncoding RNA (ncRNA) molecules with a unique covalently closed loop structure. Next-generation sequencing shows that thousands of circRNAs are widely and stably expressed in multiple eukaryotes. As novel regulatory ncRNAs, circRNAs possess several specific molecular functions, including regulating gene transcription and translation, acting as miRNA sponges, and interacting with functional proteins. Ovarian cancer (OvCa) is one of the most aggressive malignant diseases affecting the lives of thousands of women worldwide, and the majority of OvCa cases are diagnosed at advanced stages. Accumulating evidence has revealed the significant roles of circRNAs in the occurrence and progression of OvCa, indicating the function of circRNAs as promising biomarkers and their therapeutic relevance in this disease. This review aims to summarize the mechanisms by which circRNAs mediate OvCa progression as well as their diagnostic and prognostic values in OvCa. BioMed Central 2020-06-23 /pmc/articles/PMC7313187/ /pubmed/32587475 http://dx.doi.org/10.1186/s12935-020-01367-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yang, Xuejing
Mei, Jie
Wang, Huiyu
Gu, Dingyi
Ding, Junli
Liu, Chaoying
The emerging roles of circular RNAs in ovarian cancer
title The emerging roles of circular RNAs in ovarian cancer
title_full The emerging roles of circular RNAs in ovarian cancer
title_fullStr The emerging roles of circular RNAs in ovarian cancer
title_full_unstemmed The emerging roles of circular RNAs in ovarian cancer
title_short The emerging roles of circular RNAs in ovarian cancer
title_sort emerging roles of circular rnas in ovarian cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313187/
https://www.ncbi.nlm.nih.gov/pubmed/32587475
http://dx.doi.org/10.1186/s12935-020-01367-9
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