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Untargeted LC–MS/MS analysis reveals metabolomics feature of osteosarcoma stem cell response to methotrexate

BACKGROUND: Cancer stem cell (CSC) is identified in osteosarcoma (OS) and considered resistant to chemotherapeutic agents. However, the mechanism of osteosarcoma stem cell (OSC) resistant to chemotherapy remains debatable and vague, and the metabolomics feature of OSC is not clarified. MATERIALS AND...

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Detalles Bibliográficos
Autores principales:	Wang, Feng, Zhang, Zhiyu, Li, Qin, Yu, Tao, Ma, Chengbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313215/ https://www.ncbi.nlm.nih.gov/pubmed/32587477 http://dx.doi.org/10.1186/s12935-020-01356-y

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