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A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report
Melanoma is an aggressive skin cancer form with a grave prognosis. Current results suggest that oncolytic virus treatment of melanoma has a high therapeutic potential. ECHO-7 (Rigvir) is the first oncolytic virus registered in Latvia. A female patient was diagnosed with stage IIIB melanoma in Decemb...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313323/ https://www.ncbi.nlm.nih.gov/pubmed/32637110 http://dx.doi.org/10.1177/2050313X20934978 |
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author | Sorokins, Vladimirs Tilgase, Andra Olmane, Evija Isajevs, Sergejs Zablocka, Tatjana Rasa, Agnija Alberts, Pēteris |
author_facet | Sorokins, Vladimirs Tilgase, Andra Olmane, Evija Isajevs, Sergejs Zablocka, Tatjana Rasa, Agnija Alberts, Pēteris |
author_sort | Sorokins, Vladimirs |
collection | PubMed |
description | Melanoma is an aggressive skin cancer form with a grave prognosis. Current results suggest that oncolytic virus treatment of melanoma has a high therapeutic potential. ECHO-7 (Rigvir) is the first oncolytic virus registered in Latvia. A female patient was diagnosed with stage IIIB melanoma in December 2012, over 9.4 years ago. After the first excision and re-excision, the patient had several recurrences and disease progressions. After the patient had received surgical treatment in 2014, ECHO-7 virus oncolytic virotherapy was started. Since then, the patient has experienced only one more disease progression episode in May 2015 and has been stable for over 60 months. The patient has not received any other treatment than surgery and oncolytic virotherapy. No severe adverse events have been reported during virotherapy. The present case suggests that ECHO-7 virotherapy is an effective treatment of skin melanoma. |
format | Online Article Text |
id | pubmed-7313323 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-73133232020-07-06 A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report Sorokins, Vladimirs Tilgase, Andra Olmane, Evija Isajevs, Sergejs Zablocka, Tatjana Rasa, Agnija Alberts, Pēteris SAGE Open Med Case Rep Case Report Melanoma is an aggressive skin cancer form with a grave prognosis. Current results suggest that oncolytic virus treatment of melanoma has a high therapeutic potential. ECHO-7 (Rigvir) is the first oncolytic virus registered in Latvia. A female patient was diagnosed with stage IIIB melanoma in December 2012, over 9.4 years ago. After the first excision and re-excision, the patient had several recurrences and disease progressions. After the patient had received surgical treatment in 2014, ECHO-7 virus oncolytic virotherapy was started. Since then, the patient has experienced only one more disease progression episode in May 2015 and has been stable for over 60 months. The patient has not received any other treatment than surgery and oncolytic virotherapy. No severe adverse events have been reported during virotherapy. The present case suggests that ECHO-7 virotherapy is an effective treatment of skin melanoma. SAGE Publications 2020-06-23 /pmc/articles/PMC7313323/ /pubmed/32637110 http://dx.doi.org/10.1177/2050313X20934978 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report Sorokins, Vladimirs Tilgase, Andra Olmane, Evija Isajevs, Sergejs Zablocka, Tatjana Rasa, Agnija Alberts, Pēteris A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title | A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title_full | A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title_fullStr | A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title_full_unstemmed | A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title_short | A progressive stage IIIB melanoma treated with oncolytic ECHO-7 virus: A case report |
title_sort | progressive stage iiib melanoma treated with oncolytic echo-7 virus: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313323/ https://www.ncbi.nlm.nih.gov/pubmed/32637110 http://dx.doi.org/10.1177/2050313X20934978 |
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