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Feline infectious peritonitis virus-associated rhinitis in a cat
CASE SUMMARY: This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine and...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313338/ https://www.ncbi.nlm.nih.gov/pubmed/32637147 http://dx.doi.org/10.1177/2055116920930582 |
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author | André, Nicole M Miller, Andrew D Whittaker, Gary R |
author_facet | André, Nicole M Miller, Andrew D Whittaker, Gary R |
author_sort | André, Nicole M |
collection | PubMed |
description | CASE SUMMARY: This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine and small intestine. Histologic examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with monoclonal antibody FIPV3-70 targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of an FIP virus. Pathological changes, immunolabeling and molecular analysis provide evidence that respiratory infection by feline coronavirus is part of the spectrum of FIP-associated disease. RELEVANCE AND NOVEL INFORMATION: This report highlights nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry and molecular characterization of the virus. Our work supports a little-appreciated role of the respiratory tract in FIP. |
format | Online Article Text |
id | pubmed-7313338 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-73133382020-07-06 Feline infectious peritonitis virus-associated rhinitis in a cat André, Nicole M Miller, Andrew D Whittaker, Gary R JFMS Open Rep Case Report CASE SUMMARY: This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine and small intestine. Histologic examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with monoclonal antibody FIPV3-70 targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of an FIP virus. Pathological changes, immunolabeling and molecular analysis provide evidence that respiratory infection by feline coronavirus is part of the spectrum of FIP-associated disease. RELEVANCE AND NOVEL INFORMATION: This report highlights nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry and molecular characterization of the virus. Our work supports a little-appreciated role of the respiratory tract in FIP. SAGE Publications 2020-06-23 /pmc/articles/PMC7313338/ /pubmed/32637147 http://dx.doi.org/10.1177/2055116920930582 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Case Report André, Nicole M Miller, Andrew D Whittaker, Gary R Feline infectious peritonitis virus-associated rhinitis in a cat |
title | Feline infectious peritonitis virus-associated rhinitis in a cat |
title_full | Feline infectious peritonitis virus-associated rhinitis in a cat |
title_fullStr | Feline infectious peritonitis virus-associated rhinitis in a cat |
title_full_unstemmed | Feline infectious peritonitis virus-associated rhinitis in a cat |
title_short | Feline infectious peritonitis virus-associated rhinitis in a cat |
title_sort | feline infectious peritonitis virus-associated rhinitis in a cat |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313338/ https://www.ncbi.nlm.nih.gov/pubmed/32637147 http://dx.doi.org/10.1177/2055116920930582 |
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