Cargando…
Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment
The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various dis...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313454/ https://www.ncbi.nlm.nih.gov/pubmed/32486027 http://dx.doi.org/10.3390/ijms21113888 |
_version_ | 1783549940314669056 |
---|---|
author | Ouahoud, Sarah Hardwick, James C.H. Hawinkels, Lukas J.A.C. |
author_facet | Ouahoud, Sarah Hardwick, James C.H. Hawinkels, Lukas J.A.C. |
author_sort | Ouahoud, Sarah |
collection | PubMed |
description | The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various diseases, including cancer, which can arise as a consequence of dysregulated BMP signaling. Mutations in crucial elements of this signaling pathway, such as receptors, have been reported to disrupt BMP signaling. Next to that, aberrant expression of BMP antagonists could also contribute to abrogated signaling. In this review we set out to highlight how BMP antagonists affect not only the cancer cells, but also the other cells present in the microenvironment to influence cancer progression. |
format | Online Article Text |
id | pubmed-7313454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-73134542020-06-29 Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment Ouahoud, Sarah Hardwick, James C.H. Hawinkels, Lukas J.A.C. Int J Mol Sci Review The bone morphogenetic proteins (BMPs), a subgroup of the transforming growth factor-β (TGF-β) superfamily, are involved in multiple biological processes such as embryonic development and maintenance of adult tissue homeostasis. The importance of a functional BMP pathway is underlined by various diseases, including cancer, which can arise as a consequence of dysregulated BMP signaling. Mutations in crucial elements of this signaling pathway, such as receptors, have been reported to disrupt BMP signaling. Next to that, aberrant expression of BMP antagonists could also contribute to abrogated signaling. In this review we set out to highlight how BMP antagonists affect not only the cancer cells, but also the other cells present in the microenvironment to influence cancer progression. MDPI 2020-05-29 /pmc/articles/PMC7313454/ /pubmed/32486027 http://dx.doi.org/10.3390/ijms21113888 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ouahoud, Sarah Hardwick, James C.H. Hawinkels, Lukas J.A.C. Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title | Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title_full | Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title_fullStr | Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title_full_unstemmed | Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title_short | Extracellular BMP Antagonists, Multifaceted Orchestrators in the Tumor and Its Microenvironment |
title_sort | extracellular bmp antagonists, multifaceted orchestrators in the tumor and its microenvironment |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313454/ https://www.ncbi.nlm.nih.gov/pubmed/32486027 http://dx.doi.org/10.3390/ijms21113888 |
work_keys_str_mv | AT ouahoudsarah extracellularbmpantagonistsmultifacetedorchestratorsinthetumoranditsmicroenvironment AT hardwickjamesch extracellularbmpantagonistsmultifacetedorchestratorsinthetumoranditsmicroenvironment AT hawinkelslukasjac extracellularbmpantagonistsmultifacetedorchestratorsinthetumoranditsmicroenvironment |