Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair

Genomic DNA is constantly damaged by factors produced during natural metabolic processes as well as agents coming from the external environment. Considering such a wide array of damaging agents, eukaryotic cells have evolved a DNA damage response (DRR) that opposes the influence of deleterious facto...

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Detalles Bibliográficos
Autores principales: Kciuk, Mateusz, Bukowski, Karol, Marciniak, Beata, Kontek, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313471/
https://www.ncbi.nlm.nih.gov/pubmed/32486270
http://dx.doi.org/10.3390/ijms21113934
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author Kciuk, Mateusz
Bukowski, Karol
Marciniak, Beata
Kontek, Renata
author_facet Kciuk, Mateusz
Bukowski, Karol
Marciniak, Beata
Kontek, Renata
author_sort Kciuk, Mateusz
collection PubMed
description Genomic DNA is constantly damaged by factors produced during natural metabolic processes as well as agents coming from the external environment. Considering such a wide array of damaging agents, eukaryotic cells have evolved a DNA damage response (DRR) that opposes the influence of deleterious factors. Despite the broad knowledge regarding DNA damage and repair, new areas of research are emerging. New players in the field of DDR are constantly being discovered. The aim of this study is to review current knowledge regarding the roles of sirtuins, heat shock proteins, long-noncoding RNAs and the circadian clock in DDR and distinguish new agents that may have a prominent role in DNA damage response and repair.
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spelling pubmed-73134712020-06-29 Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair Kciuk, Mateusz Bukowski, Karol Marciniak, Beata Kontek, Renata Int J Mol Sci Review Genomic DNA is constantly damaged by factors produced during natural metabolic processes as well as agents coming from the external environment. Considering such a wide array of damaging agents, eukaryotic cells have evolved a DNA damage response (DRR) that opposes the influence of deleterious factors. Despite the broad knowledge regarding DNA damage and repair, new areas of research are emerging. New players in the field of DDR are constantly being discovered. The aim of this study is to review current knowledge regarding the roles of sirtuins, heat shock proteins, long-noncoding RNAs and the circadian clock in DDR and distinguish new agents that may have a prominent role in DNA damage response and repair. MDPI 2020-05-30 /pmc/articles/PMC7313471/ /pubmed/32486270 http://dx.doi.org/10.3390/ijms21113934 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kciuk, Mateusz
Bukowski, Karol
Marciniak, Beata
Kontek, Renata
Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title_full Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title_fullStr Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title_full_unstemmed Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title_short Advances in DNA Repair—Emerging Players in the Arena of Eukaryotic DNA Repair
title_sort advances in dna repair—emerging players in the arena of eukaryotic dna repair
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313471/
https://www.ncbi.nlm.nih.gov/pubmed/32486270
http://dx.doi.org/10.3390/ijms21113934
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