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Impact of Levodopa in Lung Functions in Patients with Parkinson Disease

BACKGROUND: Parkinson's disease (PD) is the second-most common neurodegenerative disorder known primarily by its motor symptomatology. These motor manifestations are also hypothesised to affect the respiratory muscular function of PD patients contributing to restrictive pattern of ventilatory d...

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Autores principales: Tandon, Medha, Ahmad, Faiz M. H., Narayanan, Subramanian, Mohan, Charu, Yadav, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313576/
https://www.ncbi.nlm.nih.gov/pubmed/32606522
http://dx.doi.org/10.4103/aian.AIAN_88_19
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author Tandon, Medha
Ahmad, Faiz M. H.
Narayanan, Subramanian
Mohan, Charu
Yadav, Simone
author_facet Tandon, Medha
Ahmad, Faiz M. H.
Narayanan, Subramanian
Mohan, Charu
Yadav, Simone
author_sort Tandon, Medha
collection PubMed
description BACKGROUND: Parkinson's disease (PD) is the second-most common neurodegenerative disorder known primarily by its motor symptomatology. These motor manifestations are also hypothesised to affect the respiratory muscular function of PD patients contributing to restrictive pattern of ventilatory dysfunction. Previous reports attempting to detect these abnormalities through spirometric assessments have been inconclusive. Attempts at reversal of the restrictive abnormalities by levodopa therapy too, have yielded conflicting results. OBJECTIVES: This study aims to classify spirometric abnormalities in asymptomatic PD patients after levopopa withdrawal and document changes after levodopa replacement. METHODS: Thirty-six non-smoker PD patients without pre-existing respiratory abnormalities were enrolled. Their standard spirometric values- FEV1, FVC and FEV1/FVC, were noted before and after their morning levodopa dose. RESULTS: Nineteen patients had abnormal PFT values at baseline - 14 restrictive and 5 obstructive defects. Fourteen patients showed improvement in their pulmonary performances after dopamine administration with 6 showing complete reversibility. Statistically significant improvement in the post-levodopa FVC values was seen in patients with restrictive disorder (P value=0.04) but not for obstructive disorders. DISCUSSIONS: This pilot study characterised that 39% of PD patients had restrictive ventilatory defects prior to morning dopamine administration. Of these, 40% showed improvement after levodopa administration. CONCLUSION: Restrictive defects are common in PD patients which are evident on routine spirometric screening. These defects are reversible on levodopa administration.
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spelling pubmed-73135762020-06-29 Impact of Levodopa in Lung Functions in Patients with Parkinson Disease Tandon, Medha Ahmad, Faiz M. H. Narayanan, Subramanian Mohan, Charu Yadav, Simone Ann Indian Acad Neurol Short Communication BACKGROUND: Parkinson's disease (PD) is the second-most common neurodegenerative disorder known primarily by its motor symptomatology. These motor manifestations are also hypothesised to affect the respiratory muscular function of PD patients contributing to restrictive pattern of ventilatory dysfunction. Previous reports attempting to detect these abnormalities through spirometric assessments have been inconclusive. Attempts at reversal of the restrictive abnormalities by levodopa therapy too, have yielded conflicting results. OBJECTIVES: This study aims to classify spirometric abnormalities in asymptomatic PD patients after levopopa withdrawal and document changes after levodopa replacement. METHODS: Thirty-six non-smoker PD patients without pre-existing respiratory abnormalities were enrolled. Their standard spirometric values- FEV1, FVC and FEV1/FVC, were noted before and after their morning levodopa dose. RESULTS: Nineteen patients had abnormal PFT values at baseline - 14 restrictive and 5 obstructive defects. Fourteen patients showed improvement in their pulmonary performances after dopamine administration with 6 showing complete reversibility. Statistically significant improvement in the post-levodopa FVC values was seen in patients with restrictive disorder (P value=0.04) but not for obstructive disorders. DISCUSSIONS: This pilot study characterised that 39% of PD patients had restrictive ventilatory defects prior to morning dopamine administration. Of these, 40% showed improvement after levodopa administration. CONCLUSION: Restrictive defects are common in PD patients which are evident on routine spirometric screening. These defects are reversible on levodopa administration. Wolters Kluwer - Medknow 2020 2020-06-10 /pmc/articles/PMC7313576/ /pubmed/32606522 http://dx.doi.org/10.4103/aian.AIAN_88_19 Text en Copyright: © 2006 - 2020 Annals of Indian Academy of Neurology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Short Communication
Tandon, Medha
Ahmad, Faiz M. H.
Narayanan, Subramanian
Mohan, Charu
Yadav, Simone
Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title_full Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title_fullStr Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title_full_unstemmed Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title_short Impact of Levodopa in Lung Functions in Patients with Parkinson Disease
title_sort impact of levodopa in lung functions in patients with parkinson disease
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313576/
https://www.ncbi.nlm.nih.gov/pubmed/32606522
http://dx.doi.org/10.4103/aian.AIAN_88_19
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