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Hexokinase II dissociation alone cannot account for changes in heart mitochondrial function, morphology and sensitivity to permeability transition pore opening following ischemia

We previously demonstrated that hexokinase II (HK2) dissociation from mitochondria during cardiac ischemia correlates with cytochrome c (cyt-c) loss, oxidative stress and subsequent reperfusion injury. However, whether HK2 release is the primary signal mediating this ischemia-induced mitochondrial d...

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Detalles Bibliográficos
Autores principales:	Pereira, Gonçalo C., Lee, Laura, Rawlings, Nadiia, Ouwendijk, Joke, Parker, Joanne E., Andrienko, Tatyana N., Henley, Jeremy M., Halestrap, Andrew P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313731/ https://www.ncbi.nlm.nih.gov/pubmed/32579577 http://dx.doi.org/10.1371/journal.pone.0234653

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