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Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington
BACKGROUND: Washington State served as the initial epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the United States. An understanding of the risk factors and clinical outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) may provide gui...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314181/ https://www.ncbi.nlm.nih.gov/pubmed/32444880 http://dx.doi.org/10.1093/cid/ciaa632 |
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author | Buckner, Frederick S McCulloch, Denise J Atluri, Vidya Blain, Michela McGuffin, Sarah A Nalla, Arun K Huang, Meei-Li Greninger, Alex L Jerome, Keith R Cohen, Seth A Neme, Santiago Green, Margaret L Chu, Helen Y Kim, H Nina |
author_facet | Buckner, Frederick S McCulloch, Denise J Atluri, Vidya Blain, Michela McGuffin, Sarah A Nalla, Arun K Huang, Meei-Li Greninger, Alex L Jerome, Keith R Cohen, Seth A Neme, Santiago Green, Margaret L Chu, Helen Y Kim, H Nina |
author_sort | Buckner, Frederick S |
collection | PubMed |
description | BACKGROUND: Washington State served as the initial epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the United States. An understanding of the risk factors and clinical outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) may provide guidance for management. METHODS: All laboratory-confirmed COVID-19 cases in adults admitted to an academic medical center in Seattle, Washington, between 2 March and 26 March 2020 were included. We evaluated individuals with and without severe disease, defined as admission to the intensive care unit or death. RESULTS: One hundred five COVID-19 patients were hospitalized. Thirty-five percent were admitted from a senior home or skilled nursing facility. The median age was 69 years, and half were women. Three or more comorbidities were present in 55% of patients, with hypertension (59%), obesity (47%), cardiovascular disease (38%), and diabetes (33%) being the most prevalent. Most (63%) had symptoms for ≥5 days prior to admission. Only 39% had fever in the first 24 hours, whereas 41% had hypoxia at admission. Seventy-three percent of patients had lymphopenia. Of 50 samples available for additional testing, no viral coinfections were identified. Severe disease occurred in 49%. Eighteen percent of patients were placed on mechanical ventilation, and the overall mortality rate was 33%. CONCLUSIONS: During the early days of the COVID-19 epidemic in Washington State, the disease had its greatest impact on elderly patients with medical comorbidities. We observed high rates of severe disease and mortality in our hospitalized patients. |
format | Online Article Text |
id | pubmed-7314181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73141812020-06-25 Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington Buckner, Frederick S McCulloch, Denise J Atluri, Vidya Blain, Michela McGuffin, Sarah A Nalla, Arun K Huang, Meei-Li Greninger, Alex L Jerome, Keith R Cohen, Seth A Neme, Santiago Green, Margaret L Chu, Helen Y Kim, H Nina Clin Infect Dis Articles and Commentaries BACKGROUND: Washington State served as the initial epicenter of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic in the United States. An understanding of the risk factors and clinical outcomes of hospitalized patients with coronavirus disease 2019 (COVID-19) may provide guidance for management. METHODS: All laboratory-confirmed COVID-19 cases in adults admitted to an academic medical center in Seattle, Washington, between 2 March and 26 March 2020 were included. We evaluated individuals with and without severe disease, defined as admission to the intensive care unit or death. RESULTS: One hundred five COVID-19 patients were hospitalized. Thirty-five percent were admitted from a senior home or skilled nursing facility. The median age was 69 years, and half were women. Three or more comorbidities were present in 55% of patients, with hypertension (59%), obesity (47%), cardiovascular disease (38%), and diabetes (33%) being the most prevalent. Most (63%) had symptoms for ≥5 days prior to admission. Only 39% had fever in the first 24 hours, whereas 41% had hypoxia at admission. Seventy-three percent of patients had lymphopenia. Of 50 samples available for additional testing, no viral coinfections were identified. Severe disease occurred in 49%. Eighteen percent of patients were placed on mechanical ventilation, and the overall mortality rate was 33%. CONCLUSIONS: During the early days of the COVID-19 epidemic in Washington State, the disease had its greatest impact on elderly patients with medical comorbidities. We observed high rates of severe disease and mortality in our hospitalized patients. Oxford University Press 2020-05-22 /pmc/articles/PMC7314181/ /pubmed/32444880 http://dx.doi.org/10.1093/cid/ciaa632 Text en © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
spellingShingle | Articles and Commentaries Buckner, Frederick S McCulloch, Denise J Atluri, Vidya Blain, Michela McGuffin, Sarah A Nalla, Arun K Huang, Meei-Li Greninger, Alex L Jerome, Keith R Cohen, Seth A Neme, Santiago Green, Margaret L Chu, Helen Y Kim, H Nina Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title | Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title_full | Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title_fullStr | Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title_full_unstemmed | Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title_short | Clinical Features and Outcomes of 105 Hospitalized Patients With COVID-19 in Seattle, Washington |
title_sort | clinical features and outcomes of 105 hospitalized patients with covid-19 in seattle, washington |
topic | Articles and Commentaries |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314181/ https://www.ncbi.nlm.nih.gov/pubmed/32444880 http://dx.doi.org/10.1093/cid/ciaa632 |
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