A brand-new cardiorenal syndrome in the COVID-19  setting

Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient’s lungs, recent data have documented that COVID-1...

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Detalles Bibliográficos
Autores principales: Apetrii, Mugurel, Enache, Stefana, Siriopol, Dimitrie, Burlacu, Alexandru, Kanbay, Asiye, Kanbay, Mehmet, Scripcariu, Dragos, Covic, Adrian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
CKJ Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314230/
https://www.ncbi.nlm.nih.gov/pubmed/32695320
http://dx.doi.org/10.1093/ckj/sfaa082
Descripción
Sumario:Coronaviruses are a major pathogen for adults, causing up to one-third of community-acquired respiratory tract infections in adults during epidemics. Although the pandemic outbreak of coronavirus disease-2019 (COVID-19) targets preferentially patient’s lungs, recent data have documented that COVID-19 causes myocarditis, acute myocardial infarction, exacerbation of heart failure and acute kidney injury. Studies show that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), similar to its predecessor SARS-CoV, engages angiotensin-converting enzyme 2 (ACE2) as the entry receptor. ACE2 is also expressed in the heart, providing a link between coronaviruses and the cardiovascular system.

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