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THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS

Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique, which removes large molecular weight particles such as autoantibodies from plasma. TPE is accepted by the American Society for Apheresis as first line treatment for some severe neuroimmune disorders. Double filtrati...

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Autores principales: Roman-Filip, Corina, Catană, Maria-Gabriela, Bereanu, Alina, Lăzăroae, Ana, Gligor, Felicia, Sava, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314295/
https://www.ncbi.nlm.nih.gov/pubmed/32595246
http://dx.doi.org/10.20471/acc.2019.58.04.08
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author Roman-Filip, Corina
Catană, Maria-Gabriela
Bereanu, Alina
Lăzăroae, Ana
Gligor, Felicia
Sava, Mihai
author_facet Roman-Filip, Corina
Catană, Maria-Gabriela
Bereanu, Alina
Lăzăroae, Ana
Gligor, Felicia
Sava, Mihai
author_sort Roman-Filip, Corina
collection PubMed
description Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique, which removes large molecular weight particles such as autoantibodies from plasma. TPE is accepted by the American Society for Apheresis as first line treatment for some severe neuroimmune disorders. Double filtration plasmapheresis (DFPP) is a newer technique in which plasma is not entirely removed, only the antibodies, using special filters. High-dose intravenous immunoglobulins are an alternative treatment for these patients but are much more expensive. We reviewed medical records of 20 patients with severe neurological diseases requiring TPE or DFPP. We analyzed the indications, complications and efficacy of these procedures. After completing the procedures, neurological improvement was recorded in 80% of the patients, 5% had no improvement, and the mortality was 15%. The rate of neurological improvement was similar to other studies. None of the patients presented catheter related complications. Systemic complications were mild, transient and completely reversible.
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spelling pubmed-73142952020-06-25 THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS Roman-Filip, Corina Catană, Maria-Gabriela Bereanu, Alina Lăzăroae, Ana Gligor, Felicia Sava, Mihai Acta Clin Croat Original Scientific Papers Therapeutic plasma exchange (TPE) is an extracorporeal blood purification technique, which removes large molecular weight particles such as autoantibodies from plasma. TPE is accepted by the American Society for Apheresis as first line treatment for some severe neuroimmune disorders. Double filtration plasmapheresis (DFPP) is a newer technique in which plasma is not entirely removed, only the antibodies, using special filters. High-dose intravenous immunoglobulins are an alternative treatment for these patients but are much more expensive. We reviewed medical records of 20 patients with severe neurological diseases requiring TPE or DFPP. We analyzed the indications, complications and efficacy of these procedures. After completing the procedures, neurological improvement was recorded in 80% of the patients, 5% had no improvement, and the mortality was 15%. The rate of neurological improvement was similar to other studies. None of the patients presented catheter related complications. Systemic complications were mild, transient and completely reversible. Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2019-12 /pmc/articles/PMC7314295/ /pubmed/32595246 http://dx.doi.org/10.20471/acc.2019.58.04.08 Text en http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Original Scientific Papers
Roman-Filip, Corina
Catană, Maria-Gabriela
Bereanu, Alina
Lăzăroae, Ana
Gligor, Felicia
Sava, Mihai
THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title_full THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title_fullStr THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title_full_unstemmed THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title_short THERAPEUTIC PLASMA EXCHANGE AND DOUBLE FILTRATION PLASMAPHERESIS IN SEVERE NEUROIMMUNE DISORDERS
title_sort therapeutic plasma exchange and double filtration plasmapheresis in severe neuroimmune disorders
topic Original Scientific Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314295/
https://www.ncbi.nlm.nih.gov/pubmed/32595246
http://dx.doi.org/10.20471/acc.2019.58.04.08
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