Cargando…

X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains

Cellular signaling via binding of the cytokines IL‐36α, β, and γ along with binding of the accessory protein IL‐36RAcP, to their cognate receptor IL‐36R is believed to play a major role in epithelial and immune cell‐mediated inflammation responses. Antagonizing the signaling cascade that results fro...

Descripción completa

Detalles Bibliográficos
Autores principales:	Larson, Eric T., Brennan, Debra L., Hickey, Eugene R., Ganesan, Raj, Kroe‐Barrett, Rachel, Farrow, Neil A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Protein Structure Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314403/ https://www.ncbi.nlm.nih.gov/pubmed/32239732 http://dx.doi.org/10.1002/pro.3862

Ejemplares similares

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor
por: Ravn, Peter, et al.
Publicado: (2013)

Dynamics of Inter-heavy Chain Interactions in Human Immunoglobulin G (IgG) Subclasses Studied by Kinetic Fab Arm Exchange
por: Rispens, Theo, et al.
Publicado: (2014)

Engineering the fragment crystallizable (Fc) region of human IgG1 multimers and monomers to fine-tune interactions with sialic acid-dependent receptors
por: Blundell, Patricia A., et al.
Publicado: (2017)

Purification, crystallization and preliminary X-ray study of the fungal laccase from Cerrena maxima
por: Lyashenko, Andrey V., et al.
Publicado: (2006)

Purification, crystallization and X-ray structures of the two manganese superoxide dismutases from Caenorhabditis elegans
por: Trinh, Chi H., et al.
Publicado: (2008)

Dissection Study on the Severe Acute Respiratory Syndrome 3C-like Protease Reveals the Critical Role of the Extra Domain in Dimerization of the Enzyme: DEFINING THE EXTRA DOMAIN AS A NEW TARGET FOR DESIGN OF HIGHLY SPECIFIC PROTEASE INHIBITORS
por: Shi, Jiahai, et al.
Publicado: (2004)

Structural Insights into the Neutralization Properties of the Fully Human, Anti-interferon Monoclonal Antibody Sifalimumab
por: Oganesyan, Vaheh, et al.
Publicado: (2015)

IgG Charge: Practical and Biological Implications
por: Yang, Danlin, et al.
Publicado: (2019)

Structural basis of specific inhibition of extracellular activation of pro- or latent myostatin by the monoclonal antibody SRK-015
por: Dagbay, Kevin B., et al.
Publicado: (2020)

Truncation, Randomization, and Selection: GENERATION OF A REDUCED LENGTH c-Jun ANTAGONIST THAT RETAINS HIGH INTERACTION STABILITY
por: Crooks, Richard O., et al.
Publicado: (2011)

Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies
por: Ganesan, Rajkumar, et al.
Publicado: (2017)

Sensing Domain Dynamics in Protein Kinase A-Iα Complexes by Solution X-ray Scattering
por: Cheng, Cecilia Y., et al.
Publicado: (2009)

X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes
por: Fisher, S. Zoë, et al.
Publicado: (2006)

Domain Motion in Cytochrome P450 Reductase: CONFORMATIONAL EQUILIBRIA REVEALED BY NMR AND SMALL-ANGLE X-RAY SCATTERING
por: Ellis, Jacqueline, et al.
Publicado: (2009)

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis
por: Towler, Paul, et al.
Publicado: (2004)

Atomic Resolution X-ray Structure of the Substrate Recognition Domain of Higher Plant Ribulose-bisphosphate Carboxylase/Oxygenase (Rubisco) Activase
por: Henderson, J. Nathan, et al.
Publicado: (2011)

X-ray Structural and Functional Studies of the Three Tandemly Linked Domains of Non-structural Protein 3 (nsp3) from Murine Hepatitis Virus Reveal Conserved Functions
por: Chen, Yafang, et al.
Publicado: (2015)

Structural and biochemical characteristics of two Staphylococcus epidermidis RNase J paralogs RNase J1 and RNase J2
por: Raj, Rishi, et al.
Publicado: (2021)

Crystal Structure of Bovine Coronavirus Spike Protein Lectin Domain
por: Peng, Guiqing, et al.
Publicado: (2012)

Crystal Structure of a Functional Dimer of the PhoQ Sensor Domain
por: Cheung, Jonah, et al.
Publicado: (2008)

Crystal Structure of the LG1-3 Region of the Laminin α2 Chain
por: Carafoli, Federico, et al.
Publicado: (2009)

Crystal Structure of Interleukin-6 in Complex with a Modified Nucleic Acid Ligand
por: Gelinas, Amy D., et al.
Publicado: (2014)

Crystal structures of inhibitor complexes of M‐PMV protease with visible flap loops
por: Wosicki, Stanislaw, et al.
Publicado: (2021)

Structure of Bacillus halmapalus α-amylase crystallized with and without the substrate analogue acarbose and maltose
por: Lyhne-Iversen, Louise, et al.
Publicado: (2006)

Crystal Structure of Colicin M, a Novel Phosphatase Specifically Imported by Escherichia coli>
por: Zeth, Kornelius, et al.
Publicado: (2008)

Fortuitous structure determination of ‘as-isolated’ Escherichia coli bacterioferritin in a novel crystal form
por: van Eerde, André, et al.
Publicado: (2006)

Crystal Structure of Severe Acute Respiratory Syndrome Coronavirus Spike Protein Fusion Core
por: Xu, Yanhui, et al.
Publicado: (2004)

Crystal structure of the catalytic C‐lobe of the HECT‐type ubiquitin ligase E6AP
por: Ries, Lena K., et al.
Publicado: (2020)

Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-containing Active Site
por: Rodriguez, Fernanda, et al.
Publicado: (2014)

Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein
por: Lee, Wei‐Chao, et al.
Publicado: (2016)

IgG cooperativity – Is there allostery? Implications for antibody functions and therapeutic antibody development
por: Yang, Danlin, et al.
Publicado: (2017)

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor
por: Underwood, Christina Rye, et al.
Publicado: (2010)

Crystal Structure of Leishmania major Oligopeptidase B Gives Insight into the Enzymatic Properties of a Trypanosomatid Virulence Factor
por: McLuskey, Karen, et al.
Publicado: (2010)

Crystal Structures of the GCaMP Calcium Sensor Reveal the Mechanism of Fluorescence Signal Change and Aid Rational Design
por: Akerboom, Jasper, et al.
Publicado: (2009)

Crystal Structure and Molecular Imaging of the Na(v) Channel β3 Subunit Indicates a Trimeric Assembly
por: Namadurai, Sivakumar, et al.
Publicado: (2014)

Crystal Structure of Arabidopsis Deg2 Protein Reveals an Internal PDZ Ligand Locking the Hexameric Resting State
por: Sun, Renhua, et al.
Publicado: (2012)

Crystal structure of the first eukaryotic bilin reductase GtPEBB reveals a flipped binding mode of dihydrobiliverdin
por: Sommerkamp, Johannes A., et al.
Publicado: (2019)

Structure of the T109S mutant of Escherichia coli dihydroorotase complexed with the inhibitor 5-fluoroorotate: catalytic activity is reflected by the crystal form
por: Lee, Mihwa, et al.
Publicado: (2007)

Crystal Structure of Staphylococcus aureus Metallopeptidase (Sapep) Reveals Large Domain Motions between the Manganese-bound and Apo-states
por: Girish, Tavarekere S., et al.
Publicado: (2010)

Crystal structure of the UBR‐box from UBR6/FBXO11 reveals domain swapping mediated by zinc binding
por: Muñoz‐Escobar, Juliana, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ibvog6klabkq8b5uok6opv2fja