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X‐ray crystal structure localizes the mechanism of inhibition of an IL‐36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains

Cellular signaling via binding of the cytokines IL‐36α, β, and γ along with binding of the accessory protein IL‐36RAcP, to their cognate receptor IL‐36R is believed to play a major role in epithelial and immune cell‐mediated inflammation responses. Antagonizing the signaling cascade that results fro...

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Detalles Bibliográficos
Autores principales:	Larson, Eric T., Brennan, Debra L., Hickey, Eugene R., Ganesan, Raj, Kroe‐Barrett, Rachel, Farrow, Neil A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Protein Structure Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314403/ https://www.ncbi.nlm.nih.gov/pubmed/32239732 http://dx.doi.org/10.1002/pro.3862

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