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Mitigation of ALS Pathology by Neuron-Specific Inhibition of Nuclear Factor Kappa B Signaling

To investigate the role of neuronal NF-κB activity in pathogenesis of amyotrophic lateral sclerosis (ALS), we generated transgenic mice with neuron-specific expression of a super-repressor form of the NF-κB inhibitor (IκBα-SR), which were then crossed with mice of both sexes, expressing ALS-linked g...

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Detalles Bibliográficos
Autores principales:	Dutta, Kallol, Thammisetty, Sai Sampath, Boutej, Hejer, Bareil, Christine, Julien, Jean-Pierre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314413/ https://www.ncbi.nlm.nih.gov/pubmed/32457070 http://dx.doi.org/10.1523/JNEUROSCI.0536-20.2020

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