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SynGAP isoforms differentially regulate synaptic plasticity and dendritic development
SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal splice variants: α1, α2, β, and γ. Although studies have implicated SYNGAP1 in several cognitive disorders, it is not clear which SynGAP isoforms contribute to disease. Here, we demonstrate that SynGAP isoforms exhibit uni...
Autores principales: | Araki, Yoichi, Hong, Ingie, Gamache, Timothy R, Ju, Shaowen, Collado-Torres, Leonardo, Shin, Joo Heon, Huganir, Richard L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314543/ https://www.ncbi.nlm.nih.gov/pubmed/32579114 http://dx.doi.org/10.7554/eLife.56273 |
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