Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

The neurotoxicity of air pollution is undefined for sex and APOE alleles. These major risk factors of Alzheimer’s disease (AD) were examined in mice given chronic exposure to nPM, a nano-sized subfraction of urban air pollution. In the cerebral cortex, female mice had two-fold more genes responding...

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Detalles Bibliográficos
Autores principales: Haghani, Amin, Cacciottolo, Mafalda, Doty, Kevin R, D'Agostino, Carla, Thorwald, Max, Safi, Nikoo, Levine, Morgan E, Sioutas, Constantinos, Town, Terrence C, Forman, Henry Jay, Zhang, Hongqiao, Morgan, Todd E, Finch, Caleb E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314548/
https://www.ncbi.nlm.nih.gov/pubmed/32579111
http://dx.doi.org/10.7554/eLife.54822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314548/
https://www.ncbi.nlm.nih.gov/pubmed/32579111
http://dx.doi.org/10.7554/eLife.54822

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