Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway

The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both seasonal and pandemic influenza vaccines. Despite its wide use and efficacy, its mechanisms of action remain unclear. In this study we demonstr...

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Detalles Bibliográficos
Autores principales: Kim, Eui Ho, Woodruff, Matthew C, Grigoryan, Lilit, Maier, Barbara, Lee, Song Hee, Mandal, Pratyusha, Cortese, Mario, Natrajan, Muktha S, Ravindran, Rajesh, Ma, Huailiang, Merad, Miriam, Gitlin, Alexander D, Mocarski, Edward S, Jacob, Joshy, Pulendran, Bali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314549/
https://www.ncbi.nlm.nih.gov/pubmed/32515732
http://dx.doi.org/10.7554/eLife.52687

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