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The origin of domestication genes in goats
Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314551/ https://www.ncbi.nlm.nih.gov/pubmed/32671210 http://dx.doi.org/10.1126/sciadv.aaz5216 |
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author | Zheng, Zhuqing Wang, Xihong Li, Ming Li, Yunjia Yang, Zhirui Wang, Xiaolong Pan, Xiangyu Gong, Mian Zhang, Yu Guo, Yingwei Wang, Yu Liu, Jing Cai, Yudong Chen, Qiuming Okpeku, Moses Colli, Licia Cai, Dawei Wang, Kun Huang, Shisheng Sonstegard, Tad S. Esmailizadeh, Ali Zhang, Wenguang Zhang, Tingting Xu, Yangbin Xu, Naiyi Yang, Yi Han, Jianlin Chen, Lei Lesur, Joséphine Daly, Kevin G. Bradley, Daniel G. Heller, Rasmus Zhang, Guojie Wang, Wen Chen, Yulin Jiang, Yu |
author_facet | Zheng, Zhuqing Wang, Xihong Li, Ming Li, Yunjia Yang, Zhirui Wang, Xiaolong Pan, Xiangyu Gong, Mian Zhang, Yu Guo, Yingwei Wang, Yu Liu, Jing Cai, Yudong Chen, Qiuming Okpeku, Moses Colli, Licia Cai, Dawei Wang, Kun Huang, Shisheng Sonstegard, Tad S. Esmailizadeh, Ali Zhang, Wenguang Zhang, Tingting Xu, Yangbin Xu, Naiyi Yang, Yi Han, Jianlin Chen, Lei Lesur, Joséphine Daly, Kevin G. Bradley, Daniel G. Heller, Rasmus Zhang, Guojie Wang, Wen Chen, Yulin Jiang, Yu |
author_sort | Zheng, Zhuqing |
collection | PubMed |
description | Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication. |
format | Online Article Text |
id | pubmed-7314551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-73145512020-07-14 The origin of domestication genes in goats Zheng, Zhuqing Wang, Xihong Li, Ming Li, Yunjia Yang, Zhirui Wang, Xiaolong Pan, Xiangyu Gong, Mian Zhang, Yu Guo, Yingwei Wang, Yu Liu, Jing Cai, Yudong Chen, Qiuming Okpeku, Moses Colli, Licia Cai, Dawei Wang, Kun Huang, Shisheng Sonstegard, Tad S. Esmailizadeh, Ali Zhang, Wenguang Zhang, Tingting Xu, Yangbin Xu, Naiyi Yang, Yi Han, Jianlin Chen, Lei Lesur, Joséphine Daly, Kevin G. Bradley, Daniel G. Heller, Rasmus Zhang, Guojie Wang, Wen Chen, Yulin Jiang, Yu Sci Adv Research Articles Goat domestication was critical for agriculture and civilization, but its underlying genetic changes and selection regimes remain unclear. Here, we analyze the genomes of worldwide domestic goats, wild caprid species, and historical remains, providing evidence of an ancient introgression event from a West Caucasian tur-like species to the ancestor of domestic goats. One introgressed locus with a strong signature of selection harbors the MUC6 gene, which encodes a gastrointestinally secreted mucin. Experiments revealed that the nearly fixed introgressed haplotype confers enhanced immune resistance to gastrointestinal pathogens. Another locus with a strong signal of selection may be related to behavior. The selected alleles at these two loci emerged in domestic goats at least 7200 and 8100 years ago, respectively, and increased to high frequencies concurrent with the expansion of the ubiquitous modern mitochondrial haplogroup A. Tracking these archaeologically cryptic evolutionary transformations provides new insights into the mechanisms of animal domestication. American Association for the Advancement of Science 2020-05-20 /pmc/articles/PMC7314551/ /pubmed/32671210 http://dx.doi.org/10.1126/sciadv.aaz5216 Text en Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Zheng, Zhuqing Wang, Xihong Li, Ming Li, Yunjia Yang, Zhirui Wang, Xiaolong Pan, Xiangyu Gong, Mian Zhang, Yu Guo, Yingwei Wang, Yu Liu, Jing Cai, Yudong Chen, Qiuming Okpeku, Moses Colli, Licia Cai, Dawei Wang, Kun Huang, Shisheng Sonstegard, Tad S. Esmailizadeh, Ali Zhang, Wenguang Zhang, Tingting Xu, Yangbin Xu, Naiyi Yang, Yi Han, Jianlin Chen, Lei Lesur, Joséphine Daly, Kevin G. Bradley, Daniel G. Heller, Rasmus Zhang, Guojie Wang, Wen Chen, Yulin Jiang, Yu The origin of domestication genes in goats |
title | The origin of domestication genes in goats |
title_full | The origin of domestication genes in goats |
title_fullStr | The origin of domestication genes in goats |
title_full_unstemmed | The origin of domestication genes in goats |
title_short | The origin of domestication genes in goats |
title_sort | origin of domestication genes in goats |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314551/ https://www.ncbi.nlm.nih.gov/pubmed/32671210 http://dx.doi.org/10.1126/sciadv.aaz5216 |
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