Cargando…

Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move between genetic lineages is an open question, which we address in the context of antibiotic resistance in Streptococcus pneumoniae. We analyze microbiological, genomic, and epidemiolog...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lehtinen, Sonja, Chewapreecha, Claire, Lees, John, Hanage, William P., Lipsitch, Marc, Croucher, Nicholas J., Bentley, Stephen D., Turner, Paul, Fraser, Christophe, Mostowy, Rafał J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2020
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314567/ https://www.ncbi.nlm.nih.gov/pubmed/32671212 http://dx.doi.org/10.1126/sciadv.aaz6137

Ejemplares similares

Horizontal DNA Transfer Mechanisms of Bacteria as Weapons of Intragenomic Conflict
por: Croucher, Nicholas J., et al.
Publicado: (2016)

An evolutionary model to predict the frequency of antibiotic resistance under seasonal antibiotic use, and an application to Streptococcus pneumoniae
por: Blanquart, François, et al.
Publicado: (2017)

Heterogeneity in the Frequency and Characteristics of Homologous Recombination in Pneumococcal Evolution
por: Mostowy, Rafal, et al.
Publicado: (2014)

Frequency-dependent selection can forecast evolution in Streptococcus pneumoniae
por: Azarian, Taj, et al.
Publicado: (2020)

Population genomic datasets describing the post-vaccine evolutionary epidemiology of Streptococcus pneumoniae
por: Croucher, Nicholas J., et al.
Publicado: (2015)

Frequency-dependent selection in vaccine-associated pneumococcal population dynamics
por: Corander, Jukka, et al.
Publicado: (2017)

The evolution of antibiotic resistance in a structured host population
por: Blanquart, François, et al.
Publicado: (2018)

Epidemiological dynamics of bacteriocin competition and antibiotic resistance
por: Lehtinen, Sonja, et al.
Publicado: (2022)

Pneumococcal Capsule Synthesis Locus cps as Evolutionary Hotspot with Potential to Generate Novel Serotypes by Recombination
por: Mostowy, Rafał J., et al.
Publicado: (2017)

Synergistic Activity of Mobile Genetic Element Defences in Streptococcus pneumoniae
por: Kwun, Min Jung, et al.
Publicado: (2019)

What is the mechanism for persistent coexistence of drug-susceptible and drug-resistant strains of Streptococcus pneumoniae?
por: Colijn, Caroline, et al.
Publicado: (2010)

Negative frequency-dependent selection and asymmetrical transformation stabilise multi-strain bacterial population structures
por: Harrow, Gabrielle L., et al.
Publicado: (2021)

On the evolutionary ecology of multidrug resistance in bacteria
por: Lehtinen, Sonja, et al.
Publicado: (2019)

Non-encapsulated Streptococcus pneumoniae, vaccination as a measure to interfere with horizontal gene transfer
por: Langereis, J. D., et al.
Publicado: (2017)

Host population structure and treatment frequency maintain balancing selection on drug resistance
por: Cobey, Sarah, et al.
Publicado: (2017)

Efficient Inference of Recent and Ancestral Recombination within Bacterial Populations
por: Mostowy, Rafal, et al.
Publicado: (2017)

The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome
por: Azarian, Taj, et al.
Publicado: (2018)

Distinct Effects on Diversifying Selection by Two Mechanisms of Immunity against Streptococcus pneumoniae
por: Li, Yuan, et al.
Publicado: (2012)

Horizontal gene transfer and recombination in Streptococcus dysgalactiae subsp. equisimilis
por: McNeilly, Celia L., et al.
Publicado: (2014)

Inhibition of Competence Development, Horizontal Gene Transfer and Virulence in Streptococcus pneumoniae by a Modified Competence Stimulating Peptide
por: Zhu, Luchang, et al.
Publicado: (2011)

The acquisition of clinically relevant amoxicillin resistance in Streptococcus pneumoniae requires ordered horizontal gene transfer of four loci
por: Gibson, Paddy S., et al.
Publicado: (2022)

Variation at the capsule locus, cps, of mistyped and non-typable Streptococcus pneumoniae isolates
por: Salter, S. J., et al.
Publicado: (2012)

Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes
por: Chewapreecha, Claire, et al.
Publicado: (2014)

Horizontal Gene Transfer of Antibiotic Resistance Genes in Biofilms
por: Michaelis, Claudia, et al.
Publicado: (2023)

Cooperative antibiotic resistance facilitates horizontal gene transfer
por: Wang, Qinqin, et al.
Publicado: (2023)

Genome-wide association, prediction and heritability in bacteria with application to Streptococcus pneumoniae
por: Mallawaarachchi, Sudaraka, et al.
Publicado: (2022)

Diverse regulatory pathways modulate bet hedging of competence induction in epigenetically-differentiated phase variants of Streptococcus pneumoniae
por: Kwun, Min Jung, et al.
Publicado: (2023)

Selective and Genetic Constraints on Pneumococcal Serotype Switching
por: Croucher, Nicholas J., et al.
Publicado: (2015)

Bacterial vaccines and serotype replacement: lessons from Haemophilus influenzae and prospects for Streptococcus pneumoniae.
por: Lipsitch, M
Publicado: (1999)

Carriage burden, multiple colonization and antibiotic pressure promote emergence of resistant vaccine escape pneumococci
por: Mitchell, Patrick K., et al.
Publicado: (2015)

Antibiotic Selection Pressure and Resistance in Streptococcus pneumoniae and Streptococcus pyogenes
por: Albrich, Werner C., et al.
Publicado: (2004)

Inferring Horizontal Gene Transfer
por: Ravenhall, Matt, et al.
Publicado: (2015)

Genomic epidemiology of penicillin-non-susceptible Streptococcus pneumoniae
por: Dewé, Tamsin C. M., et al.
Publicado: (2019)

Detection of horizontal transfer of individual genes by anomalous oligomer frequencies
por: Elhai, Jeff, et al.
Publicado: (2012)

Editorial: Horizontal Gene Transfer Mediated Bacterial Antibiotic Resistance
por: Sun, Dongchang, et al.
Publicado: (2019)

Functions predict horizontal gene transfer and the emergence of antibiotic resistance
por: Zhou, Hao, et al.
Publicado: (2021)

Generation of Genic Diversity among Streptococcus pneumoniae Strains via Horizontal Gene Transfer during a Chronic Polyclonal Pediatric Infection
por: Hiller, N. Luisa, et al.
Publicado: (2010)

Subinhibitory antibiotic concentrations promote the horizontal transfer of plasmid-borne resistance genes from Klebsiellae pneumoniae to Escherichia coli
por: Ding, Manlin, et al.
Publicado: (2022)

Exploring metabolic adaptation of Streptococcus pneumoniae to antibiotics
por: Leonard, Anne, et al.
Publicado: (2020)

Effects of Streptococcus pneumoniae Strain Background on Complement Resistance
por: Hyams, Catherine, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_6rqteb4834guq75iqf06qg19bo