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Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine

Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue...

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Autores principales: Mohammadi Nasr, Saeed, Rabiee, Navid, Hajebi, Sakineh, Ahmadi, Sepideh, Fatahi, Yousef, Hosseini, Masoumehossadat, Bagherzadeh, Mojtaba, Ghadiri, Amir Mohammad, Rabiee, Mohammad, Jajarmi, Vahid, Webster, Thomas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314574/
https://www.ncbi.nlm.nih.gov/pubmed/32606673
http://dx.doi.org/10.2147/IJN.S245936
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author Mohammadi Nasr, Saeed
Rabiee, Navid
Hajebi, Sakineh
Ahmadi, Sepideh
Fatahi, Yousef
Hosseini, Masoumehossadat
Bagherzadeh, Mojtaba
Ghadiri, Amir Mohammad
Rabiee, Mohammad
Jajarmi, Vahid
Webster, Thomas J
author_facet Mohammadi Nasr, Saeed
Rabiee, Navid
Hajebi, Sakineh
Ahmadi, Sepideh
Fatahi, Yousef
Hosseini, Masoumehossadat
Bagherzadeh, Mojtaba
Ghadiri, Amir Mohammad
Rabiee, Mohammad
Jajarmi, Vahid
Webster, Thomas J
author_sort Mohammadi Nasr, Saeed
collection PubMed
description Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature.
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spelling pubmed-73145742020-06-29 Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine Mohammadi Nasr, Saeed Rabiee, Navid Hajebi, Sakineh Ahmadi, Sepideh Fatahi, Yousef Hosseini, Masoumehossadat Bagherzadeh, Mojtaba Ghadiri, Amir Mohammad Rabiee, Mohammad Jajarmi, Vahid Webster, Thomas J Int J Nanomedicine Review Cardiovascular diseases are the number one cause of heart failure and death in the world, and the transplantation of the heart is an effective and viable choice for treatment despite presenting many disadvantages (most notably, transplant heart availability). To overcome this problem, cardiac tissue engineering is considered a promising approach by using implantable artificial blood vessels, injectable gels, and cardiac patches (to name a few) made from biodegradable polymers. Biodegradable polymers are classified into two main categories: natural and synthetic polymers. Natural biodegradable polymers have some distinct advantages such as biodegradability, abundant availability, and renewability but have some significant drawbacks such as rapid degradation, insufficient electrical conductivity, immunological reaction, and poor mechanical properties for cardiac tissue engineering. Synthetic biodegradable polymers have some advantages such as strong mechanical properties, controlled structure, great processing flexibility, and usually no immunological concerns; however, they have some drawbacks such as a lack of cell attachment and possible low biocompatibility. Some applications have combined the best of both and exciting new natural/synthetic composites have been utilized. Recently, the use of nanostructured polymers and polymer nanocomposites has revolutionized the field of cardiac tissue engineering due to their enhanced mechanical, electrical, and surface properties promoting tissue growth. In this review, recent research on the use of biodegradable natural/synthetic nanocomposite polymers in cardiac tissue engineering is presented with forward looking thoughts provided for what is needed for the field to mature. Dove 2020-06-18 /pmc/articles/PMC7314574/ /pubmed/32606673 http://dx.doi.org/10.2147/IJN.S245936 Text en © 2020 Mohammadi Nasr et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Mohammadi Nasr, Saeed
Rabiee, Navid
Hajebi, Sakineh
Ahmadi, Sepideh
Fatahi, Yousef
Hosseini, Masoumehossadat
Bagherzadeh, Mojtaba
Ghadiri, Amir Mohammad
Rabiee, Mohammad
Jajarmi, Vahid
Webster, Thomas J
Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title_full Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title_fullStr Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title_full_unstemmed Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title_short Biodegradable Nanopolymers in Cardiac Tissue Engineering: From Concept Towards Nanomedicine
title_sort biodegradable nanopolymers in cardiac tissue engineering: from concept towards nanomedicine
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314574/
https://www.ncbi.nlm.nih.gov/pubmed/32606673
http://dx.doi.org/10.2147/IJN.S245936
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