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Chronic intermittent tachypacing by an optogenetic approach induces arrhythmia vulnerability in human engineered heart tissue

AIMS: Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem cells (hiPSC) may replace animal models to overcome species differences and ethical problems. Here, 3D engineered heart ti...

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Detalles Bibliográficos
Autores principales:	Lemme, Marta, Braren, Ingke, Prondzynski, Maksymilian, Aksehirlioglu, Bülent, Ulmer, Bärbel M, Schulze, Mirja L, Ismaili, Djemail, Meyer, Christian, Hansen, Arne, Christ, Torsten, Lemoine, Marc D, Eschenhagen, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314638/ https://www.ncbi.nlm.nih.gov/pubmed/31598634 http://dx.doi.org/10.1093/cvr/cvz245

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