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Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer
Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics,...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314664/ https://www.ncbi.nlm.nih.gov/pubmed/32514151 http://dx.doi.org/10.1038/s41388-020-1341-1 |
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author | Fong, Winnie Li, Qing Yu, Jun |
author_facet | Fong, Winnie Li, Qing Yu, Jun |
author_sort | Fong, Winnie |
collection | PubMed |
description | Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT) have been employed. Although these strategies show promising results, mechanistically by correcting microbiota composition, modulating innate immune system, enhancing gut barrier function, preventing pathogen colonization and exerting selective cytotoxicity against tumor cells, it should be noted that they are accompanied by risks and controversies that can potentially introduce clinical complications. During bench-to-bedside translation, evaluation of risk-and-benefit ratio, as well as patient selection, should be carefully performed. In view of the individualized host response to gut microbiome intervention, developing personalized microbiome therapy may be the key to successful clinical treatment. |
format | Online Article Text |
id | pubmed-7314664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73146642020-06-29 Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer Fong, Winnie Li, Qing Yu, Jun Oncogene Review Article Research about the role of gut microbiome in colorectal cancer (CRC) is a newly emerging field of study. Gut microbiota modulation, with the aim to reverse established microbial dysbiosis, is a novel strategy for prevention and treatment of CRC. Different strategies including probiotics, prebiotics, postbiotics, antibiotics, and fecal microbiota transplantation (FMT) have been employed. Although these strategies show promising results, mechanistically by correcting microbiota composition, modulating innate immune system, enhancing gut barrier function, preventing pathogen colonization and exerting selective cytotoxicity against tumor cells, it should be noted that they are accompanied by risks and controversies that can potentially introduce clinical complications. During bench-to-bedside translation, evaluation of risk-and-benefit ratio, as well as patient selection, should be carefully performed. In view of the individualized host response to gut microbiome intervention, developing personalized microbiome therapy may be the key to successful clinical treatment. Nature Publishing Group UK 2020-06-08 2020 /pmc/articles/PMC7314664/ /pubmed/32514151 http://dx.doi.org/10.1038/s41388-020-1341-1 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Fong, Winnie Li, Qing Yu, Jun Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title | Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title_full | Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title_fullStr | Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title_full_unstemmed | Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title_short | Gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
title_sort | gut microbiota modulation: a novel strategy for prevention and treatment of colorectal cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314664/ https://www.ncbi.nlm.nih.gov/pubmed/32514151 http://dx.doi.org/10.1038/s41388-020-1341-1 |
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