A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19

The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong bas...

Descripción completa

Detalles Bibliográficos
Autor principal: Esam, Zohreh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314682/
https://www.ncbi.nlm.nih.gov/pubmed/32592841
http://dx.doi.org/10.1016/j.diabres.2020.108282
_version_ 1783550109179445248
author Esam, Zohreh
author_facet Esam, Zohreh
author_sort Esam, Zohreh
collection PubMed
description The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19.
format Online
Article
Text
id pubmed-7314682
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Elsevier B.V.
record_format MEDLINE/PubMed
spelling pubmed-73146822020-06-25 A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19 Esam, Zohreh Diabetes Res Clin Pract Letter to the Editor The whole world is facing a tough time these days struggling against the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is not any specific effective drug for this viral infection. Thus, we are trying to treat patients with non-specific drug cocktails. Metformin, as a strong base, a potential regulator of Vacuolar ATPase (V-ATPase) and endosomal Na+/H+ exchangers (eNHEs), additionally a regenerative agent for lung fibrosis, seems to be beneficial for patients in acute, chronic and recovery phases of COVID-19. Elsevier B.V. 2020-09 2020-06-25 /pmc/articles/PMC7314682/ /pubmed/32592841 http://dx.doi.org/10.1016/j.diabres.2020.108282 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to the Editor
Esam, Zohreh
A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title_full A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title_fullStr A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title_full_unstemmed A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title_short A proposed mechanism for the possible therapeutic potential of Metformin in COVID-19
title_sort proposed mechanism for the possible therapeutic potential of metformin in covid-19
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314682/
https://www.ncbi.nlm.nih.gov/pubmed/32592841
http://dx.doi.org/10.1016/j.diabres.2020.108282
work_keys_str_mv AT esamzohreh aproposedmechanismforthepossibletherapeuticpotentialofmetforminincovid19
AT esamzohreh proposedmechanismforthepossibletherapeuticpotentialofmetforminincovid19

Ejemplares similares