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Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314789/ https://www.ncbi.nlm.nih.gov/pubmed/32581213 http://dx.doi.org/10.1038/s41467-020-16890-6 |
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author | Hadadi, Eva Taylor, William Li, Xiao-Mei Aslan, Yetki Villote, Marthe Rivière, Julie Duvallet, Gaelle Auriau, Charlotte Dulong, Sandrine Raymond-Letron, Isabelle Provot, Sylvain Bennaceur-Griscelli, Annelise Acloque, Hervé |
author_facet | Hadadi, Eva Taylor, William Li, Xiao-Mei Aslan, Yetki Villote, Marthe Rivière, Julie Duvallet, Gaelle Auriau, Charlotte Dulong, Sandrine Raymond-Letron, Isabelle Provot, Sylvain Bennaceur-Griscelli, Annelise Acloque, Hervé |
author_sort | Hadadi, Eva |
collection | PubMed |
description | Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression. |
format | Online Article Text |
id | pubmed-7314789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-73147892020-06-26 Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice Hadadi, Eva Taylor, William Li, Xiao-Mei Aslan, Yetki Villote, Marthe Rivière, Julie Duvallet, Gaelle Auriau, Charlotte Dulong, Sandrine Raymond-Letron, Isabelle Provot, Sylvain Bennaceur-Griscelli, Annelise Acloque, Hervé Nat Commun Article Breast cancer is the most common type of cancer worldwide and one of the major causes of cancer death in women. Epidemiological studies have established a link between night-shift work and increased cancer risk, suggesting that circadian disruption may play a role in carcinogenesis. Here, we aim to shed light on the effect of chronic jetlag (JL) on mammary tumour development. To do this, we use a mouse model of spontaneous mammary tumourigenesis and subject it to chronic circadian disruption. We observe that circadian disruption significantly increases cancer-cell dissemination and lung metastasis. It also enhances the stemness and tumour-initiating potential of tumour cells and creates an immunosuppressive shift in the tumour microenvironment. Finally, our results suggest that the use of a CXCR2 inhibitor could correct the effect of JL on cancer-cell dissemination and metastasis. Altogether, our data provide a conceptual framework to better understand and manage the effects of chronic circadian disruption on breast cancer progression. Nature Publishing Group UK 2020-06-24 /pmc/articles/PMC7314789/ /pubmed/32581213 http://dx.doi.org/10.1038/s41467-020-16890-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Hadadi, Eva Taylor, William Li, Xiao-Mei Aslan, Yetki Villote, Marthe Rivière, Julie Duvallet, Gaelle Auriau, Charlotte Dulong, Sandrine Raymond-Letron, Isabelle Provot, Sylvain Bennaceur-Griscelli, Annelise Acloque, Hervé Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title | Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title_full | Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title_fullStr | Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title_full_unstemmed | Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title_short | Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
title_sort | chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314789/ https://www.ncbi.nlm.nih.gov/pubmed/32581213 http://dx.doi.org/10.1038/s41467-020-16890-6 |
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