N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury

Ischemia–reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such a...

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Autores principales: Yao, Weifeng, Han, Xue, Ge, Mian, Chen, Chaojin, Xiao, Xue, Li, Haobo, Hei, Ziqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314846/
https://www.ncbi.nlm.nih.gov/pubmed/32581252
http://dx.doi.org/10.1038/s41419-020-2686-7
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author Yao, Weifeng
Han, Xue
Ge, Mian
Chen, Chaojin
Xiao, Xue
Li, Haobo
Hei, Ziqing
author_facet Yao, Weifeng
Han, Xue
Ge, Mian
Chen, Chaojin
Xiao, Xue
Li, Haobo
Hei, Ziqing
author_sort Yao, Weifeng
collection PubMed
description Ischemia–reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. Research on RNA modifications, specifically N6-methyladenosine (m(6)A), have confirmed that they are involved in the regulation of organ I/R injury. In this review, we summarized current understanding of the regulatory roles and significance of m(6)A RNA methylation in I/R injury in different organs.
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spelling pubmed-73148462020-06-26 N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury Yao, Weifeng Han, Xue Ge, Mian Chen, Chaojin Xiao, Xue Li, Haobo Hei, Ziqing Cell Death Dis Review Article Ischemia–reperfusion (I/R) injury is common during surgery and often results in organ dysfunction. The mechanisms of I/R injury are complex, diverse, and not well understood. RNA methylation is a novel epigenetic modification that is involved in the regulation of various biological processes, such as immunity, response to DNA damage, tumorigenesis, metastasis, stem cell renewal, fat differentiation, circadian rhythms, cell development and differentiation, and cell division. Research on RNA modifications, specifically N6-methyladenosine (m(6)A), have confirmed that they are involved in the regulation of organ I/R injury. In this review, we summarized current understanding of the regulatory roles and significance of m(6)A RNA methylation in I/R injury in different organs. Nature Publishing Group UK 2020-06-24 /pmc/articles/PMC7314846/ /pubmed/32581252 http://dx.doi.org/10.1038/s41419-020-2686-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review Article
Yao, Weifeng
Han, Xue
Ge, Mian
Chen, Chaojin
Xiao, Xue
Li, Haobo
Hei, Ziqing
N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title_full N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title_fullStr N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title_full_unstemmed N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title_short N(6)-methyladenosine (m(6)A) methylation in ischemia–reperfusion injury
title_sort n(6)-methyladenosine (m(6)a) methylation in ischemia–reperfusion injury
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314846/
https://www.ncbi.nlm.nih.gov/pubmed/32581252
http://dx.doi.org/10.1038/s41419-020-2686-7
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