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Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
De novo establishment of DNA methylation is accomplished by DNMT3A and DNMT3B. Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b. We identify 355 and 333 uniquely unmethylated gene...
Autores principales: | Yagi, Masaki, Kabata, Mio, Tanaka, Akito, Ukai, Tomoyo, Ohta, Sho, Nakabayashi, Kazuhiko, Shimizu, Masahito, Hata, Kenichiro, Meissner, Alexander, Yamamoto, Takuya, Yamada, Yasuhiro |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314859/ https://www.ncbi.nlm.nih.gov/pubmed/32581223 http://dx.doi.org/10.1038/s41467-020-16989-w |
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