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The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication

Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs bec...

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Autores principales: Pádua, Diana, Figueira, Paula, Ribeiro, Inês, Almeida, Raquel, Mesquita, Patrícia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314965/
https://www.ncbi.nlm.nih.gov/pubmed/32626705
http://dx.doi.org/10.3389/fcell.2020.00442
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author Pádua, Diana
Figueira, Paula
Ribeiro, Inês
Almeida, Raquel
Mesquita, Patrícia
author_facet Pádua, Diana
Figueira, Paula
Ribeiro, Inês
Almeida, Raquel
Mesquita, Patrícia
author_sort Pádua, Diana
collection PubMed
description Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs became a crucial goal for cancer treatment. The identification of these cells has been performed by using cell-surface markers, a reliable approach, however it lacks specificity and usually differs among tumor type and in some cases even within the same type. In theory, the ideal CSC markers are those that are required to maintain their stemness features. The knowledge that CSCs exhibit characteristics comparable to normal stem cells that could be associated with the expression of similar transcription factors (TFs) including SOX2, OCT4, NANOG, KLF4 and c-Myc, and signaling pathways such as the Wnt/β-catenin, Hedgehog (Hh), Notch and PI3K/AKT/mTOR directed the attention to the use of these similarities to identify and target CSCs in different tumor types. Several studies have demonstrated that the abnormal expression of some TFs and the dysregulation of signaling pathways are associated with tumorigenesis and CSC phenotype. The disclosure of common and appropriate biomarkers for CSCs will provide an incredible tool for cancer prognosis and treatment. Therefore, this review aims to gather the new insights in gastric and colorectal CSC identification specially by using TFs as biomarkers and divulge promising drugs that have been found and tested for targeting these cells.
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spelling pubmed-73149652020-07-02 The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication Pádua, Diana Figueira, Paula Ribeiro, Inês Almeida, Raquel Mesquita, Patrícia Front Cell Dev Biol Cell and Developmental Biology Gastric and colorectal cancers have a high incidence and mortality worldwide. The presence of cancer stem cells (CSCs) within the tumor mass has been indicated as the main reason for tumor relapse, metastasis and therapy resistance, leading to poor overall survival. Thus, the elimination of CSCs became a crucial goal for cancer treatment. The identification of these cells has been performed by using cell-surface markers, a reliable approach, however it lacks specificity and usually differs among tumor type and in some cases even within the same type. In theory, the ideal CSC markers are those that are required to maintain their stemness features. The knowledge that CSCs exhibit characteristics comparable to normal stem cells that could be associated with the expression of similar transcription factors (TFs) including SOX2, OCT4, NANOG, KLF4 and c-Myc, and signaling pathways such as the Wnt/β-catenin, Hedgehog (Hh), Notch and PI3K/AKT/mTOR directed the attention to the use of these similarities to identify and target CSCs in different tumor types. Several studies have demonstrated that the abnormal expression of some TFs and the dysregulation of signaling pathways are associated with tumorigenesis and CSC phenotype. The disclosure of common and appropriate biomarkers for CSCs will provide an incredible tool for cancer prognosis and treatment. Therefore, this review aims to gather the new insights in gastric and colorectal CSC identification specially by using TFs as biomarkers and divulge promising drugs that have been found and tested for targeting these cells. Frontiers Media S.A. 2020-06-18 /pmc/articles/PMC7314965/ /pubmed/32626705 http://dx.doi.org/10.3389/fcell.2020.00442 Text en Copyright © 2020 Pádua, Figueira, Ribeiro, Almeida and Mesquita. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Pádua, Diana
Figueira, Paula
Ribeiro, Inês
Almeida, Raquel
Mesquita, Patrícia
The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title_full The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title_fullStr The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title_full_unstemmed The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title_short The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication
title_sort relevance of transcription factors in gastric and colorectal cancer stem cells identification and eradication
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314965/
https://www.ncbi.nlm.nih.gov/pubmed/32626705
http://dx.doi.org/10.3389/fcell.2020.00442
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