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EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease

Objective: We aimed to determine whether the combination of two parameters: (a) score of axial impairment and limb rigidity (SAILR) with (b) EEG global relative median power in the frequency range theta 4–8 Hz (GRMPT) predicted cognitive outcome in patients with Parkinson's disease (PD) better...

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Autores principales: Kozak, Vitalii V., Chaturvedi, Menorca, Gschwandtner, Ute, Hatz, Florian, Meyer, Antonia, Roth, Volker, Fuhr, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314977/
https://www.ncbi.nlm.nih.gov/pubmed/32625079
http://dx.doi.org/10.3389/fnagi.2020.00171
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author Kozak, Vitalii V.
Chaturvedi, Menorca
Gschwandtner, Ute
Hatz, Florian
Meyer, Antonia
Roth, Volker
Fuhr, Peter
author_facet Kozak, Vitalii V.
Chaturvedi, Menorca
Gschwandtner, Ute
Hatz, Florian
Meyer, Antonia
Roth, Volker
Fuhr, Peter
author_sort Kozak, Vitalii V.
collection PubMed
description Objective: We aimed to determine whether the combination of two parameters: (a) score of axial impairment and limb rigidity (SAILR) with (b) EEG global relative median power in the frequency range theta 4–8 Hz (GRMPT) predicted cognitive outcome in patients with Parkinson's disease (PD) better than each of these measures alone. Methods: 47 non-demented patients with PD were examined and re-examined after 3 years. At both time-points, the patients underwent a comprehensive neuropsychological and neurological assessment and EEG in eyes-closed resting-state condition. The results of cognitive tests were normalized and individually summarized to obtain a “global cognitive score” (GCS). Change of GCS was used to represent cognitive changes over time. GRMPT and SAILR was used for further analysis. Linear regression models were calculated. Results: GRMPT and SAILR independently predicted cognitive change. Combination of GRMPT and SAILR improved the significance of the regression model as compared to using each of these measures alone. GRMPT and SAILR only slightly correlate between each other. Conclusion: The combination of axial signs and rigidity with quantitative EEG improves early identification of patients with PD prone to severe cognitive decline. GRMPT and SAILR seem to reflect different disease mechanisms. Significance Combination of EEG and axial motor impairment assessment may be a valuable marker in the cognitive prognosis of PD.
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spelling pubmed-73149772020-07-02 EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease Kozak, Vitalii V. Chaturvedi, Menorca Gschwandtner, Ute Hatz, Florian Meyer, Antonia Roth, Volker Fuhr, Peter Front Aging Neurosci Neuroscience Objective: We aimed to determine whether the combination of two parameters: (a) score of axial impairment and limb rigidity (SAILR) with (b) EEG global relative median power in the frequency range theta 4–8 Hz (GRMPT) predicted cognitive outcome in patients with Parkinson's disease (PD) better than each of these measures alone. Methods: 47 non-demented patients with PD were examined and re-examined after 3 years. At both time-points, the patients underwent a comprehensive neuropsychological and neurological assessment and EEG in eyes-closed resting-state condition. The results of cognitive tests were normalized and individually summarized to obtain a “global cognitive score” (GCS). Change of GCS was used to represent cognitive changes over time. GRMPT and SAILR was used for further analysis. Linear regression models were calculated. Results: GRMPT and SAILR independently predicted cognitive change. Combination of GRMPT and SAILR improved the significance of the regression model as compared to using each of these measures alone. GRMPT and SAILR only slightly correlate between each other. Conclusion: The combination of axial signs and rigidity with quantitative EEG improves early identification of patients with PD prone to severe cognitive decline. GRMPT and SAILR seem to reflect different disease mechanisms. Significance Combination of EEG and axial motor impairment assessment may be a valuable marker in the cognitive prognosis of PD. Frontiers Media S.A. 2020-06-18 /pmc/articles/PMC7314977/ /pubmed/32625079 http://dx.doi.org/10.3389/fnagi.2020.00171 Text en Copyright © 2020 Kozak, Chaturvedi, Gschwandtner, Hatz, Meyer, Roth and Fuhr. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Kozak, Vitalii V.
Chaturvedi, Menorca
Gschwandtner, Ute
Hatz, Florian
Meyer, Antonia
Roth, Volker
Fuhr, Peter
EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title_full EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title_fullStr EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title_full_unstemmed EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title_short EEG Slowing and Axial Motor Impairment Are Independent Predictors of Cognitive Worsening in a Three-Year Cohort of Patients With Parkinson's Disease
title_sort eeg slowing and axial motor impairment are independent predictors of cognitive worsening in a three-year cohort of patients with parkinson's disease
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314977/
https://www.ncbi.nlm.nih.gov/pubmed/32625079
http://dx.doi.org/10.3389/fnagi.2020.00171
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