Cargando…

Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Backbone macrocyclic structures are often found in diverse bioactive peptides and contribute to greater conformational rigidity, peptidase resistance, and potential membrane permeability compared to their linear counterparts. Therefore, such peptide scaffolds are an attractive platform for drug-disc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shinbara, Koki, Liu, Wenyu, van Neer, Renier Herman Pieter, Katoh, Takayuki, Suga, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314982/ https://www.ncbi.nlm.nih.gov/pubmed/32626683 http://dx.doi.org/10.3389/fchem.2020.00447

Ejemplares similares

Macrocyclic Peptides Closed by a Thioether–Bipyridyl Unit That Grants Cell Membrane Permeability
por: Chen, Hongxue, et al.
Publicado: (2023)

In Vitro Selection of Macrocyclic α/β(3)-Peptides against Human EGFR
por: Wakabayashi, Risa, et al.
Publicado: (2022)

A Macrocyclic Peptide that Serves as a Cocrystallization Ligand and Inhibits the Function of a MATE Family Transporter
por: Hipolito, Christopher J., et al.
Publicado: (2013)

Technologies for the Synthesis of mRNA-Encoding Libraries and Discovery of Bioactive Natural Product-Inspired Non-Traditional Macrocyclic Peptides
por: Ito, Kenichiro, et al.
Publicado: (2013)

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides
por: Kawamura, Akane, et al.
Publicado: (2017)

Drop-off-reinitiation at the amino termini of nascent peptides and its regulation by IF3, EF-G, and RRF
por: Katoh, Takayuki, et al.
Publicado: (2023)

MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner
por: Miao, Wenyu, et al.
Publicado: (2018)

Macrocyclic Drugs and Synthetic Methodologies toward Macrocycles
por: Yu, Xufen, et al.
Publicado: (2013)

Macrocyclic peptides that inhibit Wnt signalling via interaction with Wnt3a
por: Otero-Ramirez, Manuel E., et al.
Publicado: (2020)

Linker-free incorporation of carbohydrates into in vitro displayed macrocyclic peptides
por: Jongkees, S. A. K., et al.
Publicado: (2017)

Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist
por: Miao, Wenyu, et al.
Publicado: (2018)

A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation
por: Pietz, Harlan L., et al.
Publicado: (2023)

State-selective modulation of heterotrimeric Gαs signaling with macrocyclic peptides
por: Dai, Shizhong A., et al.
Publicado: (2022)

Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins
por: Mihara, Emiko, et al.
Publicado: (2021)

Macrocyclic peptides exhibit antiviral effects against influenza virus HA and prevent pneumonia in animal models
por: Saito, Makoto, et al.
Publicado: (2021)

Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation
por: Lemma, Betsegaw, et al.
Publicado: (2023)

Macrocycle peptides delineate locked-open inhibition mechanism for microorganism phosphoglycerate mutases
por: Yu, Hao, et al.
Publicado: (2017)

In vitro selection of macrocyclic peptide inhibitors containing cyclic γ(2,4)-amino acids targeting the SARS-CoV-2 main protease
por: Miura, Takashi, et al.
Publicado: (2023)

Engineering Translation Components Improve Incorporation of Exotic Amino Acids
por: Katoh, Takayuki, et al.
Publicado: (2019)

Flexizyme-catalyzed synthesis of 3′-aminoacyl-NH-tRNAs
por: Katoh, Takayuki, et al.
Publicado: (2019)

Translation initiation with exotic amino acids using EF-P-responsive artificial initiator tRNA
por: Katoh, Takayuki, et al.
Publicado: (2023)

A comprehensive analysis of translational misdecoding pattern and its implication on genetic code evolution
por: Katoh, Takayuki, et al.
Publicado: (2023)

De novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition
por: Stefan, Erich, et al.
Publicado: (2021)

Selective macrocyclic peptide modulators of Lys63-linked ubiquitin chains disrupt DNA damage repair
por: Vamisetti, Ganga B., et al.
Publicado: (2022)

Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A
por: Matabaro, Emmanuel, et al.
Publicado: (2021)

Screening of Yeast Display Libraries of Enzymatically Treated Peptides to Discover Macrocyclic Peptide Ligands
por: Bowen, John, et al.
Publicado: (2021)

Biosynthetic Strategies for Macrocyclic Peptides
por: Wang, Wei, et al.
Publicado: (2021)

RNA-Binding Macrocyclic Peptides
por: Pal, Sunit, et al.
Publicado: (2022)

Synthesis and Screening of a DNA‐Encoded Library of Non‐Peptidic Macrocycles
por: Koesema, Eric, et al.
Publicado: (2022)

Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions
por: Sakai, Katsuya, et al.
Publicado: (2022)

Artificial human Met agonists based on macrocycle scaffolds
por: Ito, Kenichiro, et al.
Publicado: (2015)

Automated synthesis of backbone protected peptides
por: Abdel-Aal, Abu-Baker M., et al.
Publicado: (2014)

Author Correction: Identifcation, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A
por: Matabaro, Emmanuel, et al.
Publicado: (2021)

Author Correction: Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A
por: Matabaro, Emmanuel, et al.
Publicado: (2022)

Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692
por: Ayikpoe, Richard S., et al.
Publicado: (2023)

Logical engineering of D-arm and T-stem of tRNA that enhances d-amino acid incorporation
por: Katoh, Takayuki, et al.
Publicado: (2017)

Advances in in vitro genetic code reprogramming in 2014–2017
por: Katoh, Takayuki, et al.
Publicado: (2018)

Drop-off-reinitiation triggered by EF-G-driven mistranslocation and its alleviation by EF-P
por: Tajima, Kenya, et al.
Publicado: (2022)

Amino acid substrates impose polyamine, eIF5A, or hypusine requirement for peptide synthesis
por: Shin, Byung-Sik, et al.
Publicado: (2017)

Macrocyclization strategies for cyclic peptides and peptidomimetics
por: Bechtler, Clément, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o13midrm5te6f1ueruogsbh6ju