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Methodologies for Backbone Macrocyclic Peptide Synthesis Compatible With Screening Technologies

Backbone macrocyclic structures are often found in diverse bioactive peptides and contribute to greater conformational rigidity, peptidase resistance, and potential membrane permeability compared to their linear counterparts. Therefore, such peptide scaffolds are an attractive platform for drug-disc...

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Detalles Bibliográficos
Autores principales:	Shinbara, Koki, Liu, Wenyu, van Neer, Renier Herman Pieter, Katoh, Takayuki, Suga, Hiroaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314982/ https://www.ncbi.nlm.nih.gov/pubmed/32626683 http://dx.doi.org/10.3389/fchem.2020.00447

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