Changes in scaffold porosity during bone tissue engineering in perfusion bioreactors considerably affect cellular mechanical stimulation for mineralization

Bone tissue engineering (BTE) experiments in vitro have shown that fluid-induced wall shear stress (WSS) can stimulate cells to produce mineralized extracellular matrix (ECM). The application of WSS on seeded cells can be achieved through bioreactors that perfuse medium through porous scaffolds. In...

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Detalles Bibliográficos
Autores principales: Zhao, Feihu, Lacroix, Damien, Ito, Keita, van Rietbergen, Bert, Hofmann, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Articles from the Special Issue on Computational Methods in Bone Research; Edited by Dr Penny Atkins and Dr Patrik Christen
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315008/
https://www.ncbi.nlm.nih.gov/pubmed/32613033
http://dx.doi.org/10.1016/j.bonr.2020.100265

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