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The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography

OBJECTIVES: Contrast-induced nephropathy (CIN) accounts for 10% of all causes of hospital-acquired renal failure. The pathophysiological cellular mechanism of the CIN development remains unclear and seems to be multifactorial. Herein, we aimed to determine the role of red cell distribution width (RD...

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Autores principales: Sığırcı, Serhat, Şahin, İrfan, Keskin, Kudret, Yıldız, Süleyman Sezai, Çetinkal, Gökhan, Aksan, Gökhan, Çetin, Şükrü, Okuyan, Ertuğrul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kare Publishing 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315093/
https://www.ncbi.nlm.nih.gov/pubmed/32595397
http://dx.doi.org/10.14744/SEMB.2018.75537
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author Sığırcı, Serhat
Şahin, İrfan
Keskin, Kudret
Yıldız, Süleyman Sezai
Çetinkal, Gökhan
Aksan, Gökhan
Çetin, Şükrü
Okuyan, Ertuğrul
author_facet Sığırcı, Serhat
Şahin, İrfan
Keskin, Kudret
Yıldız, Süleyman Sezai
Çetinkal, Gökhan
Aksan, Gökhan
Çetin, Şükrü
Okuyan, Ertuğrul
author_sort Sığırcı, Serhat
collection PubMed
description OBJECTIVES: Contrast-induced nephropathy (CIN) accounts for 10% of all causes of hospital-acquired renal failure. The pathophysiological cellular mechanism of the CIN development remains unclear and seems to be multifactorial. Herein, we aimed to determine the role of red cell distribution width (RDW) in the development of CIN after elective percutaneous intervention in patients with stable coronary artery disease, which in our opinion has not been researched enough. METHODS: Between October 2009 and October 2011, a total of 211 patients with stable coronary artery disease who had undergone a coronary intervention procedure were evaluated prospectively. The patients were classified according to the development of CIN, and both groups were compared statistically according to clinical, laboratory, and demographic features, including the serum RDW level. RESULTS: In 18.8% of the patients, CIN was observed. The mean age was 64±10.5, and 59% of the study group was male. An advanced age, male gender, hypertension, the serum total protein level, high density lipoprotein, and albumin levels were correlated with the development of CIN. The mean RDW level was 13.7±1.4%, and the mean creatinine level was 1.0±0.2 mg/dL. There was not any correlation between RDW and the presence of CIN (CIN[−]=13.8±1.5, CIN[+]=13.6±1.0, p>0.05), and also a multivariate regression analysis proved this non-correlation (OR : 0.92, 95% confidence interval [CI]=0.62–1.34; p: 0.67 ). There was only a correlation between hypertension and male gender with CIN that was proved with a multivariate regression analysis (OR=5.74, 95% CI: 1.96–16.79, p<0.01 vs OR=5.34, 95% CI=1.22–23.3, p: 0.02, respectively). CONCLUSION: Our outcomes indicate that the RDW has a limited use as a CIN predictor in patients with stable coronary artery disease.
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spelling pubmed-73150932020-06-25 The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography Sığırcı, Serhat Şahin, İrfan Keskin, Kudret Yıldız, Süleyman Sezai Çetinkal, Gökhan Aksan, Gökhan Çetin, Şükrü Okuyan, Ertuğrul Sisli Etfal Hastan Tip Bul Research Article OBJECTIVES: Contrast-induced nephropathy (CIN) accounts for 10% of all causes of hospital-acquired renal failure. The pathophysiological cellular mechanism of the CIN development remains unclear and seems to be multifactorial. Herein, we aimed to determine the role of red cell distribution width (RDW) in the development of CIN after elective percutaneous intervention in patients with stable coronary artery disease, which in our opinion has not been researched enough. METHODS: Between October 2009 and October 2011, a total of 211 patients with stable coronary artery disease who had undergone a coronary intervention procedure were evaluated prospectively. The patients were classified according to the development of CIN, and both groups were compared statistically according to clinical, laboratory, and demographic features, including the serum RDW level. RESULTS: In 18.8% of the patients, CIN was observed. The mean age was 64±10.5, and 59% of the study group was male. An advanced age, male gender, hypertension, the serum total protein level, high density lipoprotein, and albumin levels were correlated with the development of CIN. The mean RDW level was 13.7±1.4%, and the mean creatinine level was 1.0±0.2 mg/dL. There was not any correlation between RDW and the presence of CIN (CIN[−]=13.8±1.5, CIN[+]=13.6±1.0, p>0.05), and also a multivariate regression analysis proved this non-correlation (OR : 0.92, 95% confidence interval [CI]=0.62–1.34; p: 0.67 ). There was only a correlation between hypertension and male gender with CIN that was proved with a multivariate regression analysis (OR=5.74, 95% CI: 1.96–16.79, p<0.01 vs OR=5.34, 95% CI=1.22–23.3, p: 0.02, respectively). CONCLUSION: Our outcomes indicate that the RDW has a limited use as a CIN predictor in patients with stable coronary artery disease. Kare Publishing 2018-09-28 /pmc/articles/PMC7315093/ /pubmed/32595397 http://dx.doi.org/10.14744/SEMB.2018.75537 Text en Copyright: © 2018 by The Medical Bulletin of Sisli Etfal Hospital http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
spellingShingle Research Article
Sığırcı, Serhat
Şahin, İrfan
Keskin, Kudret
Yıldız, Süleyman Sezai
Çetinkal, Gökhan
Aksan, Gökhan
Çetin, Şükrü
Okuyan, Ertuğrul
The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title_full The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title_fullStr The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title_full_unstemmed The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title_short The Impact of Red Cell Distribution Width on the Development of Contrast-Induced Nephropathy in Patients with Stable Coronary Artery Disease who Underwent Coronary Angiography
title_sort impact of red cell distribution width on the development of contrast-induced nephropathy in patients with stable coronary artery disease who underwent coronary angiography
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315093/
https://www.ncbi.nlm.nih.gov/pubmed/32595397
http://dx.doi.org/10.14744/SEMB.2018.75537
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