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Sex-Specific Effects of the Nlrp3 Inflammasome on Atherogenesis in LDL Receptor-Deficient Mice

In the Ldlr(-/-) mouse model of atherosclerosis, female Nlrp3(-/-) bone marrow chimera and Nlrp3(-/-) mice developed significantly smaller lesions in the aortic sinus and decreased lipid content in aorta en face, but a similar protection was not observed in males. Ovariectomized female mice lost pro...

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Detalles Bibliográficos
Autores principales:	Chen, Shuang, Markman, Janet L., Shimada, Kenichi, Crother, Timothy R., Lane, Malcolm, Abolhesn, Amanda, Shah, Prediman K., Arditi, Moshe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	PRECLINICAL RESEARCH
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315187/ https://www.ncbi.nlm.nih.gov/pubmed/32613145 http://dx.doi.org/10.1016/j.jacbts.2020.03.016

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