Highly Reactive Isolevuglandins Promote Atrial Fibrillation Caused by Hypertension

Oxidative damage is implicated in atrial fibrillation (AF), but antioxidants are ineffective therapeutically. The authors tested the hypothesis that highly reactive lipid dicarbonyl metabolites, or isolevuglandins (IsoLGs), are principal drivers of AF during hypertension. In a hypertensive murine mo...

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Detalles Bibliográficos
Autores principales: Prinsen, Joseph K., Kannankeril, Prince J., Sidorova, Tatiana N., Yermalitskaya, Liudmila V., Boutaud, Olivier, Zagol-Ikapitte, Irene, Barnett, Joey V., Murphy, Matthew B., Subati, Tuerdi, Stark, Joshua M., Christopher, Isis L., Jafarian-Kerman, Scott R., Saleh, Mohamed A., Norlander, Allison E., Loperena, Roxana, Atkinson, James B., Fogo, Agnes B., Luther, James M., Amarnath, Venkataraman, Davies, Sean S., Kirabo, Annet, Madhur, Meena S., Harrison, David G., Murray, Katherine T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315188/
https://www.ncbi.nlm.nih.gov/pubmed/32613146
http://dx.doi.org/10.1016/j.jacbts.2020.04.004

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