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Recent advances in understanding glucose transport and glucose disposal

Deficient glucose transport and glucose disposal are key pathologies leading to impaired glucose tolerance and risk of type 2 diabetes.  The cloning and identification of the family of facilitative glucose transporters have helped to identify that underlying mechanisms behind impaired glucose dispos...

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Autores principales: Olson, Ann Louise, Humphries, Kenneth
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315251/
https://www.ncbi.nlm.nih.gov/pubmed/32595948
http://dx.doi.org/10.12688/f1000research.22237.1
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author Olson, Ann Louise
Humphries, Kenneth
author_facet Olson, Ann Louise
Humphries, Kenneth
author_sort Olson, Ann Louise
collection PubMed
description Deficient glucose transport and glucose disposal are key pathologies leading to impaired glucose tolerance and risk of type 2 diabetes.  The cloning and identification of the family of facilitative glucose transporters have helped to identify that underlying mechanisms behind impaired glucose disposal, particularly in muscle and adipose tissue.  There is much more than just transporter protein concentration that is needed to regulate whole body glucose uptake and disposal.  The purpose of this review is to discuss recent findings in whole body glucose disposal.  We hypothesize that impaired glucose uptake and disposal is a consequence of mismatched energy input and energy output.  Decreasing the former while increasing the latter is key to normalizing glucose homeostasis.
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spelling pubmed-73152512020-06-26 Recent advances in understanding glucose transport and glucose disposal Olson, Ann Louise Humphries, Kenneth F1000Res Review Deficient glucose transport and glucose disposal are key pathologies leading to impaired glucose tolerance and risk of type 2 diabetes.  The cloning and identification of the family of facilitative glucose transporters have helped to identify that underlying mechanisms behind impaired glucose disposal, particularly in muscle and adipose tissue.  There is much more than just transporter protein concentration that is needed to regulate whole body glucose uptake and disposal.  The purpose of this review is to discuss recent findings in whole body glucose disposal.  We hypothesize that impaired glucose uptake and disposal is a consequence of mismatched energy input and energy output.  Decreasing the former while increasing the latter is key to normalizing glucose homeostasis. F1000 Research Limited 2020-06-24 /pmc/articles/PMC7315251/ /pubmed/32595948 http://dx.doi.org/10.12688/f1000research.22237.1 Text en Copyright: © 2020 Olson AL and Humphries K http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Olson, Ann Louise
Humphries, Kenneth
Recent advances in understanding glucose transport and glucose disposal
title Recent advances in understanding glucose transport and glucose disposal
title_full Recent advances in understanding glucose transport and glucose disposal
title_fullStr Recent advances in understanding glucose transport and glucose disposal
title_full_unstemmed Recent advances in understanding glucose transport and glucose disposal
title_short Recent advances in understanding glucose transport and glucose disposal
title_sort recent advances in understanding glucose transport and glucose disposal
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315251/
https://www.ncbi.nlm.nih.gov/pubmed/32595948
http://dx.doi.org/10.12688/f1000research.22237.1
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