Cargando…

Inhibition of JNK Alleviates Chronic Hypoperfusion-Related Ischemia Induces Oxidative Stress and Brain Degeneration via Nrf2/HO-1 and NF-κB Signaling

Cerebral ischemia is one of the leading causes of neurological disorders. The exact molecular mechanism related to chronic unilateral cerebral ischemia-induced neurodegeneration and memory deficit has not been precisely elucidated. In this study, we examined the effect of chronic ischemia on the ind...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Muhammad Sohail, Khan, Amjad, Ahmad, Sareer, Ahmad, Riaz, Rehman, Inayat U. R., Ikram, Muhammad, Kim, Myeong Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315317/ https://www.ncbi.nlm.nih.gov/pubmed/32617137 http://dx.doi.org/10.1155/2020/5291852

Ejemplares similares

Caffeine Modulates Cadmium-Induced Oxidative Stress, Neuroinflammation, and Cognitive Impairments by Regulating Nrf-2/HO-1 In Vivo and In Vitro
por: Khan, Amjad, et al.
Publicado: (2019)

Deciphering the Potential Neuroprotective Effects of Luteolin against Aβ(1)–(42)-Induced Alzheimer’s Disease
por: Ahmad, Sareer, et al.
Publicado: (2021)

Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways
por: Rehman, Inayat Ur, et al.
Publicado: (2022)

Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains
por: Badshah, Haroon, et al.
Publicado: (2019)

Fisetin Rescues the Mice Brains Against D-Galactose-Induced Oxidative Stress, Neuroinflammation and Memory Impairment
por: Ahmad, Sareer, et al.
Publicado: (2021)

Natural Dietary Supplementation of Curcumin Protects Mice Brains against Ethanol-Induced Oxidative Stress-Mediated Neurodegeneration and Memory Impairment via Nrf2/TLR4/RAGE Signaling
por: Ikram, Muhammad, et al.
Publicado: (2019)

Dietary Supplementation of the Antioxidant Curcumin Halts Systemic LPS-Induced Neuroinflammation-Associated Neurodegeneration and Memory/Synaptic Impairment via the JNK/NF-κB/Akt Signaling Pathway in Adult Rats
por: Khan, Muhammad Sohail, et al.
Publicado: (2019)

Cycloastragenol, a Triterpenoid Saponin, Regulates Oxidative Stress, Neurotrophic Dysfunctions, Neuroinflammation and Apoptotic Cell Death in Neurodegenerative Conditions
por: Ikram, Muhammad, et al.
Publicado: (2021)

Cadmium, an Environmental Contaminant, Exacerbates Alzheimer’s Pathology in the Aged Mice’s Brain
por: Ali, Tahir, et al.
Publicado: (2021)

Lupeol Treatment Attenuates Activation of Glial Cells and Oxidative-Stress-Mediated Neuropathology in Mouse Model of Traumatic Brain Injury
por: Ahmad, Riaz, et al.
Publicado: (2022)

Vanillic Acid, a Bioactive Phenolic Compound, Counteracts LPS-Induced Neurotoxicity by Regulating c-Jun N-Terminal Kinase in Mouse Brain
por: Ullah, Rahat, et al.
Publicado: (2020)

Lupeol, a Plant-Derived Triterpenoid, Protects Mice Brains against Aβ-Induced Oxidative Stress and Neurodegeneration
por: Ahmad, Riaz, et al.
Publicado: (2020)

Neuroprotective Effect of Quercetin Against the Detrimental Effects of LPS in the Adult Mouse Brain
por: Khan, Amjad, et al.
Publicado: (2018)

Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson’s Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment
por: Atiq, Abubakar, et al.
Publicado: (2023)

Ongoing Research on the Role of Gintonin in the Management of Neurodegenerative Disorders
por: Ikram, Muhammad, et al.
Publicado: (2020)

Pathology, Risk Factors, and Oxidative Damage Related to Type 2 Diabetes-Mediated Alzheimer's Disease and the Rescuing Effects of the Potent Antioxidant Anthocyanin
por: Khan, Muhammad Sohail, et al.
Publicado: (2021)

Antioxidant and Anti-Inflammatory Effects of Citrus Flavonoid Hesperetin: Special Focus on Neurological Disorders
por: Khan, Amjad, et al.
Publicado: (2020)

Sinapic acid alleviates 5-fluorouracil-induced nephrotoxicity in rats via Nrf2/HO-1 signalling
por: Ahmad Ansari, Mushtaq, et al.
Publicado: (2023)

Oral Administration of Alpha Linoleic Acid Rescues Aβ-Induced Glia-Mediated Neuroinflammation and Cognitive Dysfunction in C57BL/6N Mice
por: Ali, Waqar, et al.
Publicado: (2020)

Sulforaphane alleviates lung ischemia‑reperfusion injury through activating Nrf‑2/HO‑1 signaling
por: Zhang, Liang, et al.
Publicado: (2023)

Glycine, the smallest amino acid, confers neuroprotection against d-galactose-induced neurodegeneration and memory impairment by regulating c-Jun N-terminal kinase in the mouse brain
por: Ullah, Rahat, et al.
Publicado: (2020)

Gut Microbiota, Its Role in Induction of Alzheimer’s Disease Pathology, and Possible Therapeutic Interventions: Special Focus on Anthocyanins
por: Khan, Muhammad Sohail, et al.
Publicado: (2020)

17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway
por: Khan, Ibrahim, et al.
Publicado: (2021)

Nicotinamide Ameliorates Amyloid Beta-Induced Oxidative Stress-Mediated Neuroinflammation and Neurodegeneration in Adult Mouse Brain
por: Rehman, Inayat Ur, et al.
Publicado: (2021)

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury
por: Ge, Mian, et al.
Publicado: (2017)

Ulinastatin alleviates cerebral ischemia-reperfusion injury in rats by activating the Nrf-2/HO-1 signaling pathway
por: Cui, Lei, et al.
Publicado: (2020)

Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury through activating Nrf‐2/HO‐1 pathway
por: Hui, Bo, et al.
Publicado: (2022)

Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1
por: Lu, Xiao, et al.
Publicado: (2023)

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling
por: Ikram, Muhammad, et al.
Publicado: (2020)

Targeted activation of Nrf2/HO‐1 pathway by Corynoline alleviates osteoporosis development
por: Xu, Tian‐hao, et al.
Publicado: (2023)

Procyanidins Alleviated Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via the Nrf2/HO-1 Signaling Pathway
por: Chen, Lei, et al.
Publicado: (2023)

Mangiferin Alleviates Ovalbumin-Induced Allergic Rhinitis via Nrf2/HO-1/NF-κB Signaling Pathways
por: Piao, Chun Hua, et al.
Publicado: (2020)

A Triterpenoid Lupeol as an Antioxidant and Anti-Neuroinflammatory Agent: Impacts on Oxidative Stress in Alzheimer’s Disease
por: Park, Jun Sung, et al.
Publicado: (2023)

Propofol Induces the Expression of Nrf2 and HO-1 in Echinococcus granulosus via the JNK and p38 Pathway In Vitro
por: Luo, Guangyi, et al.
Publicado: (2023)

FOXC2 Alleviates Myocardial Ischemia-Reperfusion Injury in Rats through Regulating Nrf2/HO-1 Signaling Pathway
por: Wang, Rui, et al.
Publicado: (2021)

Updates on the Role of Probiotics against Different Health Issues: Focus on Lactobacillus
por: Un-Nisa, Arifa, et al.
Publicado: (2022)

Quinpirole-Mediated Regulation of Dopamine D2 Receptors Inhibits Glial Cell-Induced Neuroinflammation in Cortex and Striatum after Brain Injury
por: Alam, Sayed Ibrar, et al.
Publicado: (2021)

Paeoniflorin Resists H(2)O(2)-Induced Oxidative Stress in Melanocytes by JNK/Nrf2/HO-1 Pathway
por: Yuan, Jinping, et al.
Publicado: (2020)

6-Gingerol Alleviates Ferroptosis and Inflammation of Diabetic Cardiomyopathy via the Nrf2/HO-1 Pathway
por: Wu, Shenglin, et al.
Publicado: (2022)

Andrographolide alleviates paraquat-induced acute lung injury by activating the Nrf2/HO-1 pathway
por: Zhang, Degang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jn82u2ikrq3orcv0sruh5unkku