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Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
[Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315411/ https://www.ncbi.nlm.nih.gov/pubmed/32596562 http://dx.doi.org/10.1021/acsomega.9b04081 |
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author | Chen, Zhi-Liang Yu, Zi-Li Zhou, Miao-Miao Zhang, Song Zhang, Bing Liu, Yi Zhao, Yi-Fang Cao, Hui-Min Lin, Yi Zhang, Zhi-Ling Pang, Dai-Wen |
author_facet | Chen, Zhi-Liang Yu, Zi-Li Zhou, Miao-Miao Zhang, Song Zhang, Bing Liu, Yi Zhao, Yi-Fang Cao, Hui-Min Lin, Yi Zhang, Zhi-Ling Pang, Dai-Wen |
author_sort | Chen, Zhi-Liang |
collection | PubMed |
description | [Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (Chl) into the micelles of octylamine-modified poly(acrylic acid) (OPA). Both femtosecond transient absorption spectra and isothermal titration calorimetry thermogram reveal that the micelles of OPA provide a hydrophobic environment for the improved fluorescence efficiency. Hence the resulted Chl NCs possess unique properties such as ultrasmall size, outstanding photostability, good biocompatibility, and superbright NIR fluorescence emission. In vivo imaging of sentinel lymph node is achieved in nude mice, demonstrating the potential of Chl NCs in biomedical applications. This work provides a new strategy for the preparation of highly biocompatible NIR fluorescence labeling nanocomposites. |
format | Online Article Text |
id | pubmed-7315411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-73154112020-06-26 Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties Chen, Zhi-Liang Yu, Zi-Li Zhou, Miao-Miao Zhang, Song Zhang, Bing Liu, Yi Zhao, Yi-Fang Cao, Hui-Min Lin, Yi Zhang, Zhi-Ling Pang, Dai-Wen ACS Omega [Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (Chl) into the micelles of octylamine-modified poly(acrylic acid) (OPA). Both femtosecond transient absorption spectra and isothermal titration calorimetry thermogram reveal that the micelles of OPA provide a hydrophobic environment for the improved fluorescence efficiency. Hence the resulted Chl NCs possess unique properties such as ultrasmall size, outstanding photostability, good biocompatibility, and superbright NIR fluorescence emission. In vivo imaging of sentinel lymph node is achieved in nude mice, demonstrating the potential of Chl NCs in biomedical applications. This work provides a new strategy for the preparation of highly biocompatible NIR fluorescence labeling nanocomposites. American Chemical Society 2020-06-09 /pmc/articles/PMC7315411/ /pubmed/32596562 http://dx.doi.org/10.1021/acsomega.9b04081 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Chen, Zhi-Liang Yu, Zi-Li Zhou, Miao-Miao Zhang, Song Zhang, Bing Liu, Yi Zhao, Yi-Fang Cao, Hui-Min Lin, Yi Zhang, Zhi-Ling Pang, Dai-Wen Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties |
title | Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites:
Preparation and Optical Properties |
title_full | Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites:
Preparation and Optical Properties |
title_fullStr | Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites:
Preparation and Optical Properties |
title_full_unstemmed | Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites:
Preparation and Optical Properties |
title_short | Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites:
Preparation and Optical Properties |
title_sort | chlorophyll-based near-infrared fluorescent nanocomposites:
preparation and optical properties |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315411/ https://www.ncbi.nlm.nih.gov/pubmed/32596562 http://dx.doi.org/10.1021/acsomega.9b04081 |
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