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Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties

[Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (...

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Autores principales: Chen, Zhi-Liang, Yu, Zi-Li, Zhou, Miao-Miao, Zhang, Song, Zhang, Bing, Liu, Yi, Zhao, Yi-Fang, Cao, Hui-Min, Lin, Yi, Zhang, Zhi-Ling, Pang, Dai-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315411/
https://www.ncbi.nlm.nih.gov/pubmed/32596562
http://dx.doi.org/10.1021/acsomega.9b04081
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author Chen, Zhi-Liang
Yu, Zi-Li
Zhou, Miao-Miao
Zhang, Song
Zhang, Bing
Liu, Yi
Zhao, Yi-Fang
Cao, Hui-Min
Lin, Yi
Zhang, Zhi-Ling
Pang, Dai-Wen
author_facet Chen, Zhi-Liang
Yu, Zi-Li
Zhou, Miao-Miao
Zhang, Song
Zhang, Bing
Liu, Yi
Zhao, Yi-Fang
Cao, Hui-Min
Lin, Yi
Zhang, Zhi-Ling
Pang, Dai-Wen
author_sort Chen, Zhi-Liang
collection PubMed
description [Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (Chl) into the micelles of octylamine-modified poly(acrylic acid) (OPA). Both femtosecond transient absorption spectra and isothermal titration calorimetry thermogram reveal that the micelles of OPA provide a hydrophobic environment for the improved fluorescence efficiency. Hence the resulted Chl NCs possess unique properties such as ultrasmall size, outstanding photostability, good biocompatibility, and superbright NIR fluorescence emission. In vivo imaging of sentinel lymph node is achieved in nude mice, demonstrating the potential of Chl NCs in biomedical applications. This work provides a new strategy for the preparation of highly biocompatible NIR fluorescence labeling nanocomposites.
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spelling pubmed-73154112020-06-26 Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties Chen, Zhi-Liang Yu, Zi-Li Zhou, Miao-Miao Zhang, Song Zhang, Bing Liu, Yi Zhao, Yi-Fang Cao, Hui-Min Lin, Yi Zhang, Zhi-Ling Pang, Dai-Wen ACS Omega [Image: see text] Near-infrared (NIR) fluorescence has attracted much attention in biomedical fields because it offers deep tissue penetration and high spatial resolution. Herein, a method is developed for the preparation of NIR fluorescent nanocomposites (NCs) by encapsulating natural chlorophyll (Chl) into the micelles of octylamine-modified poly(acrylic acid) (OPA). Both femtosecond transient absorption spectra and isothermal titration calorimetry thermogram reveal that the micelles of OPA provide a hydrophobic environment for the improved fluorescence efficiency. Hence the resulted Chl NCs possess unique properties such as ultrasmall size, outstanding photostability, good biocompatibility, and superbright NIR fluorescence emission. In vivo imaging of sentinel lymph node is achieved in nude mice, demonstrating the potential of Chl NCs in biomedical applications. This work provides a new strategy for the preparation of highly biocompatible NIR fluorescence labeling nanocomposites. American Chemical Society 2020-06-09 /pmc/articles/PMC7315411/ /pubmed/32596562 http://dx.doi.org/10.1021/acsomega.9b04081 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Chen, Zhi-Liang
Yu, Zi-Li
Zhou, Miao-Miao
Zhang, Song
Zhang, Bing
Liu, Yi
Zhao, Yi-Fang
Cao, Hui-Min
Lin, Yi
Zhang, Zhi-Ling
Pang, Dai-Wen
Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title_full Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title_fullStr Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title_full_unstemmed Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title_short Chlorophyll-Based Near-Infrared Fluorescent Nanocomposites: Preparation and Optical Properties
title_sort chlorophyll-based near-infrared fluorescent nanocomposites: preparation and optical properties
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315411/
https://www.ncbi.nlm.nih.gov/pubmed/32596562
http://dx.doi.org/10.1021/acsomega.9b04081
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