Cargando…
Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents
[Image: see text] A series of spiropyran (SP)-based magnetic resonance imaging (MRI) contrast agents have been synthesized and evaluated for changes in relaxivity resulting from irradiation with visible light. Both electron-donating and electron-withdrawing substituents were appended to the SP ring...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315594/ https://www.ncbi.nlm.nih.gov/pubmed/32596613 http://dx.doi.org/10.1021/acsomega.0c01534 |
_version_ | 1783550289463214080 |
---|---|
author | Gao, Mingchun Shen, Bowen Zhou, Junhan Kapre, Rohan Louie, Angelique Y. Shaw, Jared T. |
author_facet | Gao, Mingchun Shen, Bowen Zhou, Junhan Kapre, Rohan Louie, Angelique Y. Shaw, Jared T. |
author_sort | Gao, Mingchun |
collection | PubMed |
description | [Image: see text] A series of spiropyran (SP)-based magnetic resonance imaging (MRI) contrast agents have been synthesized and evaluated for changes in relaxivity resulting from irradiation with visible light. Both electron-donating and electron-withdrawing substituents were appended to the SP ring in order to study the electronic effects on the photochromic and relaxivity properties of these photoswitchable MRI contrast agents. Photoswitches lacking an electron-withdrawing substituent isomerize readily between the merocyanine and SP forms, while the addition of a nitro group prevents this process. Complexes capable of isomerizing were demonstrated to effect a change in the relaxivity of the appended gadolinium complex. |
format | Online Article Text |
id | pubmed-7315594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-73155942020-06-26 Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents Gao, Mingchun Shen, Bowen Zhou, Junhan Kapre, Rohan Louie, Angelique Y. Shaw, Jared T. ACS Omega [Image: see text] A series of spiropyran (SP)-based magnetic resonance imaging (MRI) contrast agents have been synthesized and evaluated for changes in relaxivity resulting from irradiation with visible light. Both electron-donating and electron-withdrawing substituents were appended to the SP ring in order to study the electronic effects on the photochromic and relaxivity properties of these photoswitchable MRI contrast agents. Photoswitches lacking an electron-withdrawing substituent isomerize readily between the merocyanine and SP forms, while the addition of a nitro group prevents this process. Complexes capable of isomerizing were demonstrated to effect a change in the relaxivity of the appended gadolinium complex. American Chemical Society 2020-06-11 /pmc/articles/PMC7315594/ /pubmed/32596613 http://dx.doi.org/10.1021/acsomega.0c01534 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
spellingShingle | Gao, Mingchun Shen, Bowen Zhou, Junhan Kapre, Rohan Louie, Angelique Y. Shaw, Jared T. Synthesis and Comparative Evaluation of Photoswitchable Magnetic Resonance Imaging Contrast Agents |
title | Synthesis and Comparative Evaluation of Photoswitchable
Magnetic Resonance Imaging Contrast Agents |
title_full | Synthesis and Comparative Evaluation of Photoswitchable
Magnetic Resonance Imaging Contrast Agents |
title_fullStr | Synthesis and Comparative Evaluation of Photoswitchable
Magnetic Resonance Imaging Contrast Agents |
title_full_unstemmed | Synthesis and Comparative Evaluation of Photoswitchable
Magnetic Resonance Imaging Contrast Agents |
title_short | Synthesis and Comparative Evaluation of Photoswitchable
Magnetic Resonance Imaging Contrast Agents |
title_sort | synthesis and comparative evaluation of photoswitchable
magnetic resonance imaging contrast agents |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315594/ https://www.ncbi.nlm.nih.gov/pubmed/32596613 http://dx.doi.org/10.1021/acsomega.0c01534 |
work_keys_str_mv | AT gaomingchun synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents AT shenbowen synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents AT zhoujunhan synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents AT kaprerohan synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents AT louieangeliquey synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents AT shawjaredt synthesisandcomparativeevaluationofphotoswitchablemagneticresonanceimagingcontrastagents |