Cargando…

Synthesis and Evaluation of Novel Anticancer Compounds Derived from the Natural Product Brevilin A

[Image: see text] Cancer is the second leading cause of death globally, responsible for an estimated 9.6 million deaths in 2018, and this burden continues to increase. Therefore, there is a clear and urgent need for novel drugs with increased efficacy for the treatment of different cancers. Previous...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Magnolia Muk-Lan, Chan, Brandon Dow, Wong, Wing-Yan, Leung, Tsz-Wing, Qu, Zhao, Huang, Junrong, Zhu, Lizhi, Lee, Chi-Sing, Chen, Sibao, Tai, William Chi-Shing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315608/ https://www.ncbi.nlm.nih.gov/pubmed/32596596 http://dx.doi.org/10.1021/acsomega.0c01276

Ejemplares similares

Centipeda minima Extract Attenuates Dextran Sodium Sulfate-Induced Acute Colitis in Mice by Inhibiting Macrophage Activation and Monocyte Chemotaxis
por: Chan, Brandon Dow, et al.
Publicado: (2021)

Brevilin A Induces Cell Cycle Arrest and Apoptosis in Nasopharyngeal Carcinoma
por: Liu, Rui, et al.
Publicado: (2019)

Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds
por: Zhu, Lizhi, et al.
Publicado: (2018)

Anti-cancer Activity of Centipeda minima Extract in Triple Negative Breast Cancer via Inhibition of AKT, NF-κB, and STAT3 Signaling Pathways
por: Lee, Magnolia Muk-Lan, et al.
Publicado: (2020)

Brevilin A, a Natural Sesquiterpene Lactone Inhibited the Growth of Triple-Negative Breast Cancer Cells via Akt/mTOR and STAT3 Signaling Pathways
por: Qu, Zhao, et al.
Publicado: (2020)

Gynostemma pentaphyllum saponins attenuate inflammation in vitro and in vivo by inhibition of NF-κB and STAT3 signaling
por: Wong, Wing-Yan, et al.
Publicado: (2017)

Lactobacillus casei Strain Shirota Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Increasing Taurine-Conjugated Bile Acids and Inhibiting NF-κB Signaling via Stabilization of IκBα
por: Wong, Wing-Yan, et al.
Publicado: (2022)

Arnicolide D, from the herb Centipeda minima, Is a Therapeutic Candidate against Nasopharyngeal Carcinoma
por: Liu, Rui, et al.
Publicado: (2019)

Isolation and characterization of ZK002, a novel dual function snake venom protein from Deinagkistrodon acutus with anti-angiogenic and anti-inflammatory properties
por: Chan, Brandon Dow, et al.
Publicado: (2023)

Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction
por: Wei, Bailing, et al.
Publicado: (2022)

Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells
por: Wang, Jie, et al.
Publicado: (2018)

Brevilin A, a Sesquiterpene Lactone, Inhibits the Replication of Influenza A Virus In Vitro and In Vivo
por: Zhang, Xiaoli, et al.
Publicado: (2019)

A smart “off–on” gate for the in situ detection of hydrogen sulphide with Cu(ii)-assisted europium emission
por: Liang, Zhenhao, et al.
Publicado: (2016)

Brevilin A exerts anti-colorectal cancer effects and potently inhibits STAT3 signaling invitro
por: Meng, Mingjing, et al.
Publicado: (2023)

Brevilin A, a Novel Natural Product, Inhibits Janus Kinase Activity and Blocks STAT3 Signaling in Cancer Cells
por: Chen, Xing, et al.
Publicado: (2013)

Arnicolide D Inhibits Triple Negative Breast Cancer Cell Proliferation by Suppression of Akt/mTOR and STAT3 Signaling Pathways
por: Qu, Zhao, et al.
Publicado: (2020)

Brevilin A Ameliorates Imiquimod-Induced Psoriasis-like Dermatitis and Reduces Th17 Differentiation in Psoriasis Patients
por: Yen, Ling-Jung, et al.
Publicado: (2022)

Brevilin A Isolated from Centipeda minima Induces Apoptosis in Human Gastric Cancer Cells via an Extrinsic Apoptotic Signaling Pathway
por: Lee, Dahae, et al.
Publicado: (2022)

In vitro evaluation of anti-hepatoma activity of brevilin A: involvement of Stat3/Snail and Wnt/β-catenin pathways
por: Qin, Yaguang, et al.
Publicado: (2019)

Brevilin A induces ROS-dependent apoptosis and suppresses STAT3 activation by direct binding in human lung cancer cells
por: Khan, Muhammad, et al.
Publicado: (2020)

Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma
por: Huang, Mohan, et al.
Publicado: (2023)

The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions
por: Li, Xuan, et al.
Publicado: (2016)

High Prevalence of Astigmatism in Children after School Suspension during the COVID-19 Pandemic Is Associated with Axial Elongation
por: Wong, Suei-Cheng, et al.
Publicado: (2022)

Brevilin A Ameliorates Acute Lung Injury and Inflammation Through Inhibition of NF-κB Signaling via Targeting IKKα/β
por: Liu, Lu, et al.
Publicado: (2022)

Brevilin A is a potent anti-metastatic CRC agent that targets the VEGF-IL6-STAT3 axis in the HSCs-CRC interplay
por: Fan, Xueying, et al.
Publicado: (2023)

Blue-Light Filtering Spectacle Lenses: Optical and Clinical Performances
por: Leung, Tsz Wing, et al.
Publicado: (2017)

Mouse strain-specific polymorphic provirus functions as cis-regulatory element leading to epigenomic and transcriptomic variations
por: Zhou, Xuemeng, et al.
Publicado: (2021)

Coronavirus disease 2019 (COVID-19) outbreak during a Chinese New Year dinner in a restaurant, Hong Kong Special Administrative Region SAR (China), 2020
por: Lam, Tsz-sum, et al.
Publicado: (2021)

Changes in corneal astigmatism and near heterophoria after smartphone use while walking and sitting
por: Leung, Tsz Wing, et al.
Publicado: (2020)

Primary yolk sac tumour of the urinary bladder: A case report and review of the literature
por: MUI, WING HO, et al.
Publicado: (2014)

Ventricular Tachyarrhythmia Risk in Paediatric/Young vs. Adult Brugada Syndrome Patients: A Territory-Wide Study
por: Lee, Sharen, et al.
Publicado: (2021)

Brevilin A Inhibits STAT3 Signaling and Induces ROS-Dependent Apoptosis, Mitochondrial Stress and Endoplasmic Reticulum Stress in MCF-7 Breast Cancer Cells
por: Saleem, Muhammad Zubair, et al.
Publicado: (2020)

Prevalence and risk factors of fractures in transfusion dependent thalassemia – A Hong Kong Chinese population cohort
por: Lee, Samantha Lai Ka, et al.
Publicado: (2022)

Interpol review of toxicology 2016–2019
por: Chan, Wing-sum, et al.
Publicado: (2020)

Electrochemical Assessment of Anticancer Compounds on the Human Tongue Squamous Carcinoma Cells
por: Huang, Chun-Chung, et al.
Publicado: (2020)

The function of natural compounds in important anticancer mechanisms
por: Nan, Yang, et al.
Publicado: (2023)

Anticancer Activity of Natural Products and Related Compounds
por: De Filippis, Barbara, et al.
Publicado: (2023)

Autologous hematopoietic stem cell transplantation for high-risk brain tumors in children
por: Cheuk, Daniel Ka Leung, et al.
Publicado: (2007)

Throwing the dart blind-folded: comparison of computed tomography versus magnetic resonance imaging-guided brachytherapy for cervical cancer with regard to dose received by the ‘actual’ targets and organs at risk
por: Yip, Winnie Wing Ling, et al.
Publicado: (2017)

Measuring Retinal Thickness and Visual Acuity in Eyes with Different Types of Astigmatism in a Cohort of Hong Kong Chinese Adults
por: Liang, Dong, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_5g7sjcc3phqdqor996i011nhvg