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Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk
BACKGROUND. There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 5...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315877/ https://www.ncbi.nlm.nih.gov/pubmed/32093798 http://dx.doi.org/10.1192/j.eurpsy.2019.4 |
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author | Cristóbal-Narváez, Paula Sheinbaum, Tamara Rosa, Araceli de Castro-Catala, Marta Domínguez-Martínez, Tecelli Kwapil, Thomas R. Barrantes-Vidal, Neus |
author_facet | Cristóbal-Narváez, Paula Sheinbaum, Tamara Rosa, Araceli de Castro-Catala, Marta Domínguez-Martínez, Tecelli Kwapil, Thomas R. Barrantes-Vidal, Neus |
author_sort | Cristóbal-Narváez, Paula |
collection | PubMed |
description | BACKGROUND. There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts. METHODS. A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080). RESULTS. Multilevel analyses indicated that, unlike the risk haplotype, the protective FKBP5 haplotype moderated all the associations of positive experiences with diminished PEs and NA in incipient psychosis compared with nonclinical group. CONCLUSIONS. Participants with incipient psychosis showed symptomatic improvement when reporting positive appraisals in the interpersonal domain, which suggests that these act as a powerful coping mechanism. The fact that this occurred in daily-life underscores the clinical significance of this finding and pinpoints the importance of identifying protective mechanisms. In addition, results seem to concur with the vantage sensitivity model of gene–environment interaction, which poses that certain genetic variants may enhance the likelihood of benefiting from positive exposures. |
format | Online Article Text |
id | pubmed-7315877 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-73158772020-07-07 Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk Cristóbal-Narváez, Paula Sheinbaum, Tamara Rosa, Araceli de Castro-Catala, Marta Domínguez-Martínez, Tecelli Kwapil, Thomas R. Barrantes-Vidal, Neus Eur Psychiatry Research Article BACKGROUND. There is limited research on the interaction of both positive and negative daily-life environments with stress-related genetic variants on psychotic experiences (PEs) and negative affect (NA) across the extended psychosis phenotype. This study examined whether the FK506 binding protein 51 (FKBP5) variability moderates the association of positive and negative experiences in the moment with PEs and NA in participants with incipient psychosis and their nonclinical counterparts. METHODS. A total of 233 nonclinical and 86 incipient psychosis participants were prompted for a 1-week period to assess their day-to-day experiences. Participants were genotyped for four FKBP5 single nucleotide polymorphisms (rs3800373, rs9296158, rs1360780, and rs9470080). RESULTS. Multilevel analyses indicated that, unlike the risk haplotype, the protective FKBP5 haplotype moderated all the associations of positive experiences with diminished PEs and NA in incipient psychosis compared with nonclinical group. CONCLUSIONS. Participants with incipient psychosis showed symptomatic improvement when reporting positive appraisals in the interpersonal domain, which suggests that these act as a powerful coping mechanism. The fact that this occurred in daily-life underscores the clinical significance of this finding and pinpoints the importance of identifying protective mechanisms. In addition, results seem to concur with the vantage sensitivity model of gene–environment interaction, which poses that certain genetic variants may enhance the likelihood of benefiting from positive exposures. Cambridge University Press 2020-02-07 /pmc/articles/PMC7315877/ /pubmed/32093798 http://dx.doi.org/10.1192/j.eurpsy.2019.4 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by-nc-nd/4.0/ http://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. |
spellingShingle | Research Article Cristóbal-Narváez, Paula Sheinbaum, Tamara Rosa, Araceli de Castro-Catala, Marta Domínguez-Martínez, Tecelli Kwapil, Thomas R. Barrantes-Vidal, Neus Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title | Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title_full | Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title_fullStr | Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title_full_unstemmed | Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title_short | Interaction of both positive and negative daily-life experiences with FKBP5 haplotype on psychosis risk |
title_sort | interaction of both positive and negative daily-life experiences with fkbp5 haplotype on psychosis risk |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315877/ https://www.ncbi.nlm.nih.gov/pubmed/32093798 http://dx.doi.org/10.1192/j.eurpsy.2019.4 |
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