Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

Pathogenic clostridial species secrete potent toxins that induce severe host tissue damage. Paeniclostridium sordellii lethal toxin (TcsL) causes an almost invariably lethal toxic shock syndrome associated with gynecological infections. TcsL is 87% similar to C. difficile TcdB, which enters host cel...

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Detalles Bibliográficos
Autores principales: Lee, Hunsang, Beilhartz, Greg L., Kucharska, Iga, Raman, Swetha, Cui, Hong, Lam, Mandy Hiu Yi, Liang, Huazhu, Rubinstein, John L., Schramek, Daniel, Julien, Jean-Philippe, Melnyk, Roman A., Taipale, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316060/
https://www.ncbi.nlm.nih.gov/pubmed/32589945
http://dx.doi.org/10.1016/j.cell.2020.06.005

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