Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic

Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red cell requirements may be achievable.

Detalles Bibliográficos
Autores principales: Nickel, Robert Sheppard, Margulies, Stefanie, Frazer, Brittany, Luban, Naomi L.C., Webb, Jennifer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2020
Materias:
Letter to Blood
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316219/
https://www.ncbi.nlm.nih.gov/pubmed/32403134
http://dx.doi.org/10.1182/blood.2020006582
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author Nickel, Robert Sheppard
Margulies, Stefanie
Frazer, Brittany
Luban, Naomi L.C.
Webb, Jennifer
author_facet Nickel, Robert Sheppard
Margulies, Stefanie
Frazer, Brittany
Luban, Naomi L.C.
Webb, Jennifer
author_sort Nickel, Robert Sheppard
collection PubMed
description Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red cell requirements may be achievable.
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spelling pubmed-73162192020-07-06 Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic Nickel, Robert Sheppard Margulies, Stefanie Frazer, Brittany Luban, Naomi L.C. Webb, Jennifer Blood Letter to Blood Nickel et al describe a single-arm trial using dose-escalated hydroxyurea and regular transfusions to prevent complications of sickle cell anemia. Preliminary results suggest that a reduction in volume of red cell requirements may be achievable. American Society of Hematology 2020-06-18 2020-12-14 /pmc/articles/PMC7316219/ /pubmed/32403134 http://dx.doi.org/10.1182/blood.2020006582 Text en Copyright © 2020 American Society of Hematology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Letter to Blood
Nickel, Robert Sheppard
Margulies, Stefanie
Frazer, Brittany
Luban, Naomi L.C.
Webb, Jennifer
Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title_full Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title_fullStr Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title_full_unstemmed Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title_short Combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the COVID-19 pandemic
title_sort combination dose-escalated hydroxyurea and transfusion: an approach to conserve blood during the covid-19 pandemic
topic Letter to Blood
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316219/
https://www.ncbi.nlm.nih.gov/pubmed/32403134
http://dx.doi.org/10.1182/blood.2020006582
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