Identification of a novel toxicophore in anti-cancer chemotherapeutics that targets mitochondrial respiratory complex I

Disruption of mitochondrial function selectively targets tumour cells that are dependent on oxidative phosphorylation. However, due to their high energy demands, cardiac cells are disproportionately targeted by mitochondrial toxins resulting in a loss of cardiac function. An analysis of the effects...

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Detalles Bibliográficos
Autores principales: Stephenson, Zoe A, Harvey, Robert F, Pryde, Kenneth R, Mistry, Sarah, Hardy, Rachel E, Serreli, Riccardo, Chung, Injae, Allen, Timothy EH, Stoneley, Mark, MacFarlane, Marion, Fischer, Peter M, Hirst, Judy, Kellam, Barrie, Willis, Anne E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316505/
https://www.ncbi.nlm.nih.gov/pubmed/32432547
http://dx.doi.org/10.7554/eLife.55845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316505/
https://www.ncbi.nlm.nih.gov/pubmed/32432547
http://dx.doi.org/10.7554/eLife.55845

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